TY - GEN
T1 - Osteoconductivity and bioresorption of an interconnecting porous carbonate apatite with enhanced mechanical strength
AU - Tram, Nguyen Xuan Thanh
AU - Maruta, Michito
AU - Tusru, Kanji
AU - Matsuya, Shigeki
AU - Ishikawa, Kunio
PY - 2016/1/1
Y1 - 2016/1/1
N2 - We have established a processing method to fabricate three-dimensional porous carbonate apatite (CO3Ap) with interconnected porous structure and improved mechanical strength. Briefly, porous CO3Ap materials were produced via phosphorization of porous calcite precursor in hydrothermal condition. In order to make porous calcite precursor, negative replication of modified polyurethane foam template was conducted. In this study, an in vivo behavior of that porous CO3Ap was evaluated. The interconnected porous CO3Ap material was implanted in the tibia of Japanese male rabbits and removed after a period of 6 months. Micro-computed tomography (μ-CT) scanner and histological analysis were used to characterize the bone formation response of the porous CO3Ap. The results suggest that porous CO3Ap with enhanced mechanical strength was not only osteoconductive but also bioresorbable therefore it could be used as bone substitute material.
AB - We have established a processing method to fabricate three-dimensional porous carbonate apatite (CO3Ap) with interconnected porous structure and improved mechanical strength. Briefly, porous CO3Ap materials were produced via phosphorization of porous calcite precursor in hydrothermal condition. In order to make porous calcite precursor, negative replication of modified polyurethane foam template was conducted. In this study, an in vivo behavior of that porous CO3Ap was evaluated. The interconnected porous CO3Ap material was implanted in the tibia of Japanese male rabbits and removed after a period of 6 months. Micro-computed tomography (μ-CT) scanner and histological analysis were used to characterize the bone formation response of the porous CO3Ap. The results suggest that porous CO3Ap with enhanced mechanical strength was not only osteoconductive but also bioresorbable therefore it could be used as bone substitute material.
UR - http://www.scopus.com/inward/record.url?scp=84973473603&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84973473603&partnerID=8YFLogxK
U2 - 10.4028/www.scientific.net/KEM.696.23
DO - 10.4028/www.scientific.net/KEM.696.23
M3 - Conference contribution
AN - SCOPUS:84973473603
SN - 9783035710403
T3 - Key Engineering Materials
SP - 23
EP - 26
BT - Bioceramics 27
A2 - Ana, Ika Dewi
A2 - Triyana, Kuwat
PB - Trans Tech Publications Ltd
T2 - 27th Symposium and Annual Meeting of the International Society for Ceramics in Medicine, 2015
Y2 - 27 October 2015 through 29 October 2015
ER -