Outcome differences between children and adolescents and young adults with non-Hodgkin lymphoma following stem cell transplantation

Ryoji Kobayashi, Tetsuo Mitsui, Naoto Fujita, Tomoo Osumi, Tomohiro Aoki, Kazunari Aoki, Ritsuro Suzuki, Takahiro Fukuda, Toshihiro Miyamoto, Koji Kato, Hirohisa Nakamae, Hiroaki Goto, Tetsuya Eto, Masami Inoue, Takehiko Mori, Kiminori Terui, Masahito Onizuka, Katsuyoshi Koh, Yuhki Koga, Tatsuo IchinoheAkihisa Sawada, Yoshiko Atsuta, Junji Suzumiya

研究成果: Contribution to journalArticle査読

5 被引用数 (Scopus)

抄録

Several studies of patients with acute lymphoblastic leukemia and acute myeloid leukemia who received stem cell transplantation (SCT) have reported that adolescents and young adults (AYAs) experience higher transplant-related mortality than that in younger children. However, to the best of our knowledge, there have been no reports of a similar comparison of non-Hodgkin lymphoma (NHL) patients who received SCT. We analyzed 918 patients aged 30 years and younger who received their first stem cell transplantation for NHL. Of the allogeneic transplant patients, children and AYAs did not significantly differ in survival rate, event-free survival rate, relapse rate, or transplant-related mortality. However, 5-year transplant-related mortality after autologous transplantation was significantly higher in children than in AYAs (5.1% in children vs. 0.8% in AYAs, P = 0.0043). The cause of transplant-related death in three of four children was interstitial pneumonitis. In NHL patients, transplantation results in AYAs were not inferior than those in children.

本文言語英語
ページ(範囲)369-376
ページ数8
ジャーナルInternational journal of hematology
105
3
DOI
出版ステータス出版済み - 3 1 2017

All Science Journal Classification (ASJC) codes

  • 血液学

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