Outcome in 146 patients with paediatric acute myeloid leukaemia treated according to the AML99 protocol in the period 2003-06 from the Japan Association of Childhood Leukaemia Study

Toshihiko Imamura, Shotaro Iwamoto, Rie Kanai, Akira Shimada, Kiminori Terui, Yuko Osugi, Ryoji Kobayashi, Akio Tawa, Yoshiyuki Kosaka, Koji Kato, Hiroki Hori, Keizo Horibe, Megumi Oda, Souichi Adachi

研究成果: ジャーナルへの寄稿学術誌査読

19 被引用数 (Scopus)

抄録

The acute myeloid leukaemia (AML) 99 trial conducted previously in Japan for the treatment of de novo paediatric AML showed excellent results, with a 5-year overall survival (OS) and event-free survival (EFS) of 75·6% and 61·6%, respectively. To examine reproducibility of these results in another cohort, the outcome of 146 newly diagnosed AML paediatric patients prospectively registered in the Japan Association of Childhood Leukaemia Study (JACLS) from 2003 to 2006 was compared to that of 240 patients in the original AML 99 clinical trial. The 5-year EFS and OS achieved in the new cohort was 66·7 ± 4·0% and 77·7 ± 8·0% respectively, which were comparable to those obtained in the original AML 99 clinical trial, although less frequent core-binding factor (CBF) AML (29·5% vs. 37%) and an almost equal frequency of allogeneic haematopoietic stem cell transplantation (allo-HSCT) during first complete remission (16·5% vs. 19%) were observed. The 5-year EFS in patients with a normal karyotype (NK) (n = 35, 54·9 ± 15·1%) was inferior in the present cohort when compared to the original AML99 trial. This study confirmed the excellent outcome of the original AML99 protocol.

本文言語英語
ページ(範囲)204-210
ページ数7
ジャーナルBritish Journal of Haematology
159
2
DOI
出版ステータス出版済み - 10月 2012
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 血液学

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