TY - JOUR
T1 - Outcome of a pulmonary metastasectomy for an orthopedic malignancy
AU - Suemitsu, Ryuichi
AU - Yoshino, Ichiro
AU - Tomiyasu, Makiko
AU - Ondo, Kaoru
AU - Ueda, Hitoshi
AU - Iwamoto, Yukihide
AU - Maehara, Yoshihiko
PY - 2005/8
Y1 - 2005/8
N2 - Objective: The purpose of this study was to examine the pulmonary metastatic results in patients with orthopedic malignancies. Methods: Forty-three consecutive patients who underwent a resection of a pulmonary metastasis from an orthopedic malignancy in our hospital were retrospectively investigated. The survival following the resection of a pulmonary metastatic tumor was then analyzed using the Kaplan-Meier method. The impact of clinicopathologic variables on the prognosis including gender, patient age, primary tumor type, the number of the pulmonary metastases, the number of metastasectomies, the operation-era, and the disease-free interval was examined by the Logrank test and Cox's proportional hazards model. Results: The 5-year overall survivals after a pulmonary metastasectomy were 20.7%. A univariate analysis revealed a significant benefit in the post-metastasectomy survival based on the patients age and the disease-free interval. A multivariate analysis demonstrated patient age to be an independent factor for the prognosis with a hazard ratio of 4.873 (p=0.0373). When only young (less than 40 years of age) patients were investigated, the histologic type was revealed to be related to the prognosis (p=0.0004). Conclusion: Pulmonary metastasis from soft tissue tumors is considered to lead to a poor prognosis for younger patients and a metastasectomy for such patients should be considered as one of the potentially effective treatments.
AB - Objective: The purpose of this study was to examine the pulmonary metastatic results in patients with orthopedic malignancies. Methods: Forty-three consecutive patients who underwent a resection of a pulmonary metastasis from an orthopedic malignancy in our hospital were retrospectively investigated. The survival following the resection of a pulmonary metastatic tumor was then analyzed using the Kaplan-Meier method. The impact of clinicopathologic variables on the prognosis including gender, patient age, primary tumor type, the number of the pulmonary metastases, the number of metastasectomies, the operation-era, and the disease-free interval was examined by the Logrank test and Cox's proportional hazards model. Results: The 5-year overall survivals after a pulmonary metastasectomy were 20.7%. A univariate analysis revealed a significant benefit in the post-metastasectomy survival based on the patients age and the disease-free interval. A multivariate analysis demonstrated patient age to be an independent factor for the prognosis with a hazard ratio of 4.873 (p=0.0373). When only young (less than 40 years of age) patients were investigated, the histologic type was revealed to be related to the prognosis (p=0.0004). Conclusion: Pulmonary metastasis from soft tissue tumors is considered to lead to a poor prognosis for younger patients and a metastasectomy for such patients should be considered as one of the potentially effective treatments.
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U2 - 10.1007/s11748-005-0077-8
DO - 10.1007/s11748-005-0077-8
M3 - Article
C2 - 16164253
AN - SCOPUS:24344462706
VL - 53
SP - 420
EP - 425
JO - General Thoracic and Cardiovascular Surgery
JF - General Thoracic and Cardiovascular Surgery
SN - 1863-6705
IS - 8
ER -