Outcomes of hepatic resection for huge hepatocellular carcinoma (a≥10cm in diameter)

Yo Ichi Yamashita, Akinobu Taketomi, Ken Shirabe, Shinichi Aishima, Eiji Tsuijita, Kazutoyo Morita, Hiroto Kayashima, Yoshihiko Maehara

研究成果: Contribution to journalReview article査読

56 被引用数 (Scopus)

抄録

Background The object of the current study was to review the outcomes of hepatic resection for hepatocellular carcinoma (HCC)10cm. Methods Between 1995 and 2007, fifty-three patients with HCC-0cm underwent hepatic resection, and clinical data were compared to those of patients with non-surgical treatment (n=12). Surgical results for HCC-10cm were compared to those of patients with HCC<10cm (n=412). The independent poor prognostic factors of the patients with HCC-10cm were identified. Results Overall survival was significantly better in patients with hepatic resection for HCC-10cm than in those with non-surgical treatment (P<0.01). Survival rates of patients with hepatic resection for HCC-10cm were 35% at 5 years. Morbidity and mortality rate were statistically equal. The independent poor prognostic factors of patients with hepatic resection for HCC-10cm were revealed: T4 status, macroscopic tumor thrombus in portal vein (VP+), and the use of intra-operative transfusion. Conclusion Hepatic resections for HCC-10cm are safe and efficacious. Minimizing intra-operative blood loss and the establishment of an effective systemic treatment for patients with HCC-10cm in T4 appear to be critical.

本文言語英語
ページ(範囲)292-298
ページ数7
ジャーナルJournal of Surgical Oncology
104
3
DOI
出版ステータス出版済み - 9 1 2011

All Science Journal Classification (ASJC) codes

  • 外科
  • 腫瘍学

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