Overexpression of angiotensin-converting enzyme in myelomonocytic cells enhances the immune response

Kenneth E. Bernstein, Zakir Khan, Jorge F. Giani, Tuantuan Zhao, Masahiro Eriguchi, Ellen A. Bernstein, Romer A. Gonzalez-Villalobos, Xiao Z. Shen

研究成果: Contribution to journalReview article査読

6 被引用数 (Scopus)

抄録

Angiotensin-converting enzyme (ACE) converts angiotensin I to the vasoconstrictor angiotensin II and thereby plays an important role in blood pressure control. However, ACE is relatively non-specific in its substrate specificity and cleaves many other peptides. Recent analysis of mice overexpressing ACE in monocytes, macrophages, and other myelomonocytic cells shows that these animals have a marked increase in resistance to experimental melanoma and to infection by Listeria monocytogenes or methicillin-resistant Staphylococcus aureus (MRSA). Several other measures of immune responsiveness, including antibody production, are enhanced in these animals. These studies complement a variety of studies indicating an important role of ACE in the immune response.

本文言語英語
論文番号7508.1
ジャーナルF1000Research
5
DOI
出版ステータス出版済み - 2016

All Science Journal Classification (ASJC) codes

  • 生化学、遺伝学、分子生物学(全般)
  • 免疫学および微生物学(全般)
  • 薬理学、毒性学および薬学(全般)

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