Overexpression of FGFR1 promotes peritoneal dissemination via epithelial-to-mesenchymal transition in gastric cancer

Dai Shimizu, Tomoko Saito, I. T.O. Shuhei, Takaaki Masuda, Junji Kurashige, Yosuke Kuroda, Hidetoshi Eguchi, Yasuhiro Kodera, Koshi Mimori

研究成果: Contribution to journalArticle査読

9 被引用数 (Scopus)

抄録

Background: Peritoneal dissemination (PD) is one of the most common causes of cancer-related mortality in gastric cancer (GC). We aimed to identify PD-associated genes and investigate their role in GC. Materials and Methods: We identified FGFR1 as a putative PD-associated gene using a bioinformatics approach. The biological significance of FGFR1 in epithelial-to-mesenchymal transition (EMT) was evaluated according to the correlation with genes that participated in EMT and FGFR1 knockdown experiments. The associations between FGFR1 expression and the clinicopathological features were examined. Results: FGFR1 expression positively correlated with SNAI1, VIM and ZEB1 expression, and negatively correlated with CDH1 expression. Knockdown of FGFR1 suppressed the malignant phenotype of GC cells. High FGFR1 expression significantly correlated with the peritoneal lavage cytology and synchronous PD positivity as well as poor prognosis. Conclusion: High FGFR1 expression was associated with PD via promotion of EMT and led to a poor prognosis of GC patients.

本文言語英語
ページ(範囲)313-320
ページ数8
ジャーナルCancer Genomics and Proteomics
15
4
DOI
出版ステータス出版済み - 7 1 2018
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子生物学
  • 遺伝学
  • 癌研究

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