Overexpression of Id-1 is associated with tumor angiogenesis and poor clinical outcome in oral squamous cell carcinoma

Zuoqing Dong, Shaohua Liu, Chengjun Zhou, Tomoki sumida, Hiroyuki Hamakawa, Zhenggang Chen, Pei Liu, Fengcai Wei

研究成果: Contribution to journalArticle査読

18 被引用数 (Scopus)

抄録

We analyzed the expression of Id-1 in oral squamous cell carcinoma (OSCC) immunohistochemically, and investigated the association of Id-1 expression with tumor angiogenesis and clinical prognosis. Overexpression of Id-1 protein was found in 83 out of 128 cases (64.8%). The expression of Id-1 was significantly associated with tumor size (p = 0.013), lymph node metastasis (p = 0.001), tumor stage (p = 0.031) and tumor recurrence (p = 0.003). Moreover, Id-1 expression was significantly correlated with intratumoral microvessel density (MVD) (r = 0.223, p = 0.011). The results suggest that overexpression of Id-1 was correlated with tumor angiogenesis and poor clinical outcome.

本文言語英語
ページ(範囲)154-157
ページ数4
ジャーナルOral Oncology
46
3
DOI
出版ステータス出版済み - 3 2010

All Science Journal Classification (ASJC) codes

  • Oral Surgery
  • Oncology
  • Cancer Research

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