Overexpression of IL-15 in vivo enhances Tc1 response, which inhibits allergic inflammation in murine model of asthma

R. Ishimitsu, H. Nishimura, T. Yajima, T. Watase, H. Kawauchi, Y. Yoshikai

    研究成果: ジャーナルへの寄稿学術誌査読

    58 被引用数 (Scopus)

    抄録

    IL-15, a pleiotropic cytokine, is involved in the inflammatory responses in various infectious and autoimmune diseases. We have recently constructed IL-154-transgenic (Tg) mice, which have an increased number of memory-type CD8+ T cells in the peripheral lymphoid tissues. In the present study, we found that eosinophilia and Th2-type cytokine production in the airway were severely attenuated in OVA-sensitized IL-15-Tg mice following OVA inhalation. IL-15-Tg mice preferentially developed Tc1 responses mediated by CD8+ T cells after OVA sensitization, and in vivo depletion of CD8+ T cells by anti-CD8 mAb aggravated the allergic airway inflammation in IL-15-Tg mice following OVA inhalation. Adoptive transfer of CD8+ T cells from OVA-sensitized IL-15-Tg mice into normal mice before OVA sensitization suppressed Th2, response to OVA in the normal mice. These results suggest that overexpression of IL-15 in vivo suppresses Th2-mediated-allergic airway response via induction of CD8+ T cell-mediated Tc1 response.

    本文言語英語
    ページ(範囲)1991-2001
    ページ数11
    ジャーナルJournal of Immunology
    166
    3
    DOI
    出版ステータス出版済み - 2月 1 2001

    !!!All Science Journal Classification (ASJC) codes

    • 免疫アレルギー学
    • 免疫学

    フィンガープリント

    「Overexpression of IL-15 in vivo enhances Tc1 response, which inhibits allergic inflammation in murine model of asthma」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

    引用スタイル