抄録
The expression of p16(INK4a) has been reported to induce cell-cycle arrest and cellular senescence. The p16(INK4a) expression has never been examined in human mast cells and mastocytosis. We immunohistologically examined the expression of p16(INK4a) and tryptase in 5 normal human skin and 4 mastocytosis. In normal mast cells, only 5.9 ± 3.4 (mean ± standard deviation) % of tryptase-positive mast cells coexpressed p16(INK4a). However, significantly higher percentage (86.0 ± 14.1%) of tryptase-positive tumor cells was immunoreactive to p16(INK4a) in all of 4 mastocytosis. The p16(INK4a) overexpression may induce the senescence of neoplastic mast cells to undergo spontaneous regression of mastocytosis.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 12-17 |
| ページ数 | 6 |
| ジャーナル | Fukuoka igaku zasshi = Hukuoka acta medica |
| 巻 | 107 |
| 発行部数 | 1 |
| 出版物ステータス | 出版済み - 1 1 2016 |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
これを引用
Overexpression of p16(INK4a) in Mastocytosis (Urticarial Pigmentosa). / Tsujita, Jun; Doi, Kazuko; Nakahara, Makiko; Nakahara, Takeshi; Kaku, Yumiko; Nishio, Kiichiro; Kan, Nagisa; Sato, Yuki; Nagata, Shoko; Nakao, Asako; Yoshida, Maiko; Hiroshi, Uchi; Furue, Masutaka.
：: Fukuoka igaku zasshi = Hukuoka acta medica, 巻 107, 番号 1, 01.01.2016, p. 12-17.研究成果: ジャーナルへの寄稿 › 記事
}
TY - JOUR
T1 - Overexpression of p16(INK4a) in Mastocytosis (Urticarial Pigmentosa)
AU - Tsujita, Jun
AU - Doi, Kazuko
AU - Nakahara, Makiko
AU - Nakahara, Takeshi
AU - Kaku, Yumiko
AU - Nishio, Kiichiro
AU - Kan, Nagisa
AU - Sato, Yuki
AU - Nagata, Shoko
AU - Nakao, Asako
AU - Yoshida, Maiko
AU - Hiroshi, Uchi
AU - Furue, Masutaka
PY - 2016/1/1
Y1 - 2016/1/1
N2 - The expression of p16(INK4a) has been reported to induce cell-cycle arrest and cellular senescence. The p16(INK4a) expression has never been examined in human mast cells and mastocytosis. We immunohistologically examined the expression of p16(INK4a) and tryptase in 5 normal human skin and 4 mastocytosis. In normal mast cells, only 5.9 ± 3.4 (mean ± standard deviation) % of tryptase-positive mast cells coexpressed p16(INK4a). However, significantly higher percentage (86.0 ± 14.1%) of tryptase-positive tumor cells was immunoreactive to p16(INK4a) in all of 4 mastocytosis. The p16(INK4a) overexpression may induce the senescence of neoplastic mast cells to undergo spontaneous regression of mastocytosis.
AB - The expression of p16(INK4a) has been reported to induce cell-cycle arrest and cellular senescence. The p16(INK4a) expression has never been examined in human mast cells and mastocytosis. We immunohistologically examined the expression of p16(INK4a) and tryptase in 5 normal human skin and 4 mastocytosis. In normal mast cells, only 5.9 ± 3.4 (mean ± standard deviation) % of tryptase-positive mast cells coexpressed p16(INK4a). However, significantly higher percentage (86.0 ± 14.1%) of tryptase-positive tumor cells was immunoreactive to p16(INK4a) in all of 4 mastocytosis. The p16(INK4a) overexpression may induce the senescence of neoplastic mast cells to undergo spontaneous regression of mastocytosis.
UR - http://www.scopus.com/inward/record.url?scp=84979093263&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84979093263&partnerID=8YFLogxK
M3 - Article
C2 - 27333655
AN - SCOPUS:84979093263
VL - 107
SP - 12
EP - 17
JO - Fukuoka Acta Medica
JF - Fukuoka Acta Medica
SN - 0016-254X
IS - 1
ER -