Overexpression of p16(INK4a) in Mastocytosis (Urticarial Pigmentosa)

Jun Tsujita; Kazuko Doi; Makiko Nakahara; Takeshi Nakahara; Yumiko Kaku; Kiichiro Nishio; Nagisa Kan; Yuki Sato; Shoko Nagata; Asako Nakao; Maiko Yoshida; Uchi Hiroshi; Masutaka Furue

Overexpression of p16(INK4a) in Mastocytosis (Urticarial Pigmentosa)

Jun Tsujita, Kazuko Doi, Makiko Nakahara, Takeshi Nakahara, Yumiko Kaku, Kiichiro Nishio, Nagisa Kan, Yuki Sato, Shoko Nagata, Asako Nakao, Maiko Yoshida, Uchi Hiroshi, Masutaka Furue

研究成果: Contribution to journal › Article › 査読

抄録

The expression of p16(INK4a) has been reported to induce cell-cycle arrest and cellular senescence. The p16(INK4a) expression has never been examined in human mast cells and mastocytosis. We immunohistologically examined the expression of p16(INK4a) and tryptase in 5 normal human skin and 4 mastocytosis. In normal mast cells, only 5.9 ± 3.4 (mean ± standard deviation) % of tryptase-positive mast cells coexpressed p16(INK4a). However, significantly higher percentage (86.0 ± 14.1%) of tryptase-positive tumor cells was immunoreactive to p16(INK4a) in all of 4 mastocytosis. The p16(INK4a) overexpression may induce the senescence of neoplastic mast cells to undergo spontaneous regression of mastocytosis.

本文言語	英語
ページ（範囲）	12-17
ページ数	6
ジャーナル	Fukuoka igaku zasshi = Hukuoka acta medica
巻	107
号	1
出版ステータス	出版済み - 1 1 2016

All Science Journal Classification (ASJC) codes

Medicine(all)

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引用スタイル

Overexpression of p16(INK4a) in Mastocytosis (Urticarial Pigmentosa). / Tsujita, Jun; Doi, Kazuko; Nakahara, Makiko ; Nakahara, Takeshi; Kaku, Yumiko; Nishio, Kiichiro; Kan, Nagisa; Sato, Yuki; Nagata, Shoko; Nakao, Asako; Yoshida, Maiko; Hiroshi, Uchi; Furue, Masutaka.

In: Fukuoka igaku zasshi = Hukuoka acta medica, Vol. 107, No. 1, 01.01.2016, p. 12-17.

研究成果: Contribution to journal › Article › 査読

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abstract = "The expression of p16(INK4a) has been reported to induce cell-cycle arrest and cellular senescence. The p16(INK4a) expression has never been examined in human mast cells and mastocytosis. We immunohistologically examined the expression of p16(INK4a) and tryptase in 5 normal human skin and 4 mastocytosis. In normal mast cells, only 5.9 ± 3.4 (mean ± standard deviation) % of tryptase-positive mast cells coexpressed p16(INK4a). However, significantly higher percentage (86.0 ± 14.1%) of tryptase-positive tumor cells was immunoreactive to p16(INK4a) in all of 4 mastocytosis. The p16(INK4a) overexpression may induce the senescence of neoplastic mast cells to undergo spontaneous regression of mastocytosis.",

author = "Jun Tsujita and Kazuko Doi and Makiko Nakahara and Takeshi Nakahara and Yumiko Kaku and Kiichiro Nishio and Nagisa Kan and Yuki Sato and Shoko Nagata and Asako Nakao and Maiko Yoshida and Uchi Hiroshi and Masutaka Furue",

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AU - Doi, Kazuko

AU - Nakahara, Makiko

AU - Nakahara, Takeshi

AU - Kaku, Yumiko

AU - Nishio, Kiichiro

AU - Kan, Nagisa

AU - Sato, Yuki

AU - Nagata, Shoko

AU - Nakao, Asako

AU - Yoshida, Maiko

AU - Hiroshi, Uchi

AU - Furue, Masutaka

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AB - The expression of p16(INK4a) has been reported to induce cell-cycle arrest and cellular senescence. The p16(INK4a) expression has never been examined in human mast cells and mastocytosis. We immunohistologically examined the expression of p16(INK4a) and tryptase in 5 normal human skin and 4 mastocytosis. In normal mast cells, only 5.9 ± 3.4 (mean ± standard deviation) % of tryptase-positive mast cells coexpressed p16(INK4a). However, significantly higher percentage (86.0 ± 14.1%) of tryptase-positive tumor cells was immunoreactive to p16(INK4a) in all of 4 mastocytosis. The p16(INK4a) overexpression may induce the senescence of neoplastic mast cells to undergo spontaneous regression of mastocytosis.

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