抄録
The expression of p16(INK4a) has been reported to induce cell-cycle arrest and cellular senescence. The p16(INK4a) expression has never been examined in human mast cells and mastocytosis. We immunohistologically examined the expression of p16(INK4a) and tryptase in 5 normal human skin and 4 mastocytosis. In normal mast cells, only 5.9 ± 3.4 (mean ± standard deviation) % of tryptase-positive mast cells coexpressed p16(INK4a). However, significantly higher percentage (86.0 ± 14.1%) of tryptase-positive tumor cells was immunoreactive to p16(INK4a) in all of 4 mastocytosis. The p16(INK4a) overexpression may induce the senescence of neoplastic mast cells to undergo spontaneous regression of mastocytosis.
本文言語 | 英語 |
---|---|
ページ(範囲) | 12-17 |
ページ数 | 6 |
ジャーナル | Fukuoka igaku zasshi = Hukuoka acta medica |
巻 | 107 |
号 | 1 |
出版ステータス | 出版済み - 1 1 2016 |
All Science Journal Classification (ASJC) codes
- Medicine(all)