Overexpression of p53 nuclear protein in premalignant and malignant laryngeal lesions

Torahiko Nakashima, X. F. Wang, M. Masuda, A. Inokuchi, S. Komiyama

研究成果: ジャーナルへの寄稿記事

10 引用 (Scopus)

抄録

To investigate the role of p53 nuclear protein mutations in the initiation and progression of laryngeal carcinoma, 111 premalignant and malignant laryngeal lesions (19 specimens with hyperkeratosis and 92 with carcinoma) were studied immunohistochemically. Overexpression of p53 was observed in 8 cases (42%) of laryngeal hyperkeratosis and 44 cases (47%) of laryngeal carcinoma. However, the expression of p53 showed no relationship to patients' clinical courses. Our study confirms that p53 overexpression can be found in laryngeal carcinogenesis and is an early event but not a useful prognostic marker.

元の言語英語
ジャーナルEuropean Archives of Oto-Rhino-Laryngology
256
発行部数SUPPL. 1
DOI
出版物ステータス出版済み - 5 10 1999

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Nuclear Proteins
Carcinoma
Carcinogenesis
Mutation

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

これを引用

Overexpression of p53 nuclear protein in premalignant and malignant laryngeal lesions. / Nakashima, Torahiko; Wang, X. F.; Masuda, M.; Inokuchi, A.; Komiyama, S.

:: European Archives of Oto-Rhino-Laryngology, 巻 256, 番号 SUPPL. 1, 10.05.1999.

研究成果: ジャーナルへの寄稿記事

Nakashima, Torahiko ; Wang, X. F. ; Masuda, M. ; Inokuchi, A. ; Komiyama, S. / Overexpression of p53 nuclear protein in premalignant and malignant laryngeal lesions. :: European Archives of Oto-Rhino-Laryngology. 1999 ; 巻 256, 番号 SUPPL. 1.
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