Overexpression of phosphorylated-STAT3 and phosphorylated-ERK protein in dermatofibrosarcoma protuberans

Nengxing Lin, Kazunori Urabe, Yoichi Moroi, Uchi Hiroshi, Takeshi Nakahara, Teruki Dainichi, Hisashi Kokuba, Yating Tu, Masutaka Furue

研究成果: ジャーナルへの寄稿記事

8 引用 (Scopus)

抄録

The overexpression of phosphorylated signal transducer and activator of transcription-3 (p-STAT3) and phosphorylated extracellular signal-regulated kinase (p-ERK) have recently been shown to play an important role in the pathogenesis of various human tumors. However, the role of these two major signal transduction pathways in dermatofibrosarcoma protuberans (DFSP) remains unknown. This study was designed to investigate the significance of p-STAT3 and p-ERK expression in DFSP. The expressions of p-STAT3 and p-ERK were analyzed by immunohistochemical staining in formalin-fixed, paraffin-embedded tissue sections of human DFSP and dermatofibroma. Ten cases were positive for p-STAT3 expression in 14 cases of DFSP, however, only 5 cases were positive in 20 cases of dermatofibroma. Eleven out of 14 cases of DFSP expressed p-ERK, but only four cases were positive in 20 cases of dermatofibroma. The expressions of p-STAT3 and p-ERK were significantly higher than those in dermatofibroma (both p < 0.01). This study suggests that the overexpression of p-STAT3 and p-ERK may play a pivotal role in the oncogenesis of DFSP.

元の言語英語
ページ(範囲)262-265
ページ数4
ジャーナルEuropean Journal of Dermatology
16
発行部数3
出版物ステータス出版済み - 5 1 2006

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Dermatofibrosarcoma
STAT3 Transcription Factor
Extracellular Signal-Regulated MAP Kinases
Benign Fibrous Histiocytoma
Proteins
Paraffin
Formaldehyde
Signal Transduction
Carcinogenesis
Staining and Labeling

All Science Journal Classification (ASJC) codes

  • Dermatology

これを引用

Overexpression of phosphorylated-STAT3 and phosphorylated-ERK protein in dermatofibrosarcoma protuberans. / Lin, Nengxing; Urabe, Kazunori; Moroi, Yoichi; Hiroshi, Uchi; Nakahara, Takeshi; Dainichi, Teruki; Kokuba, Hisashi; Tu, Yating; Furue, Masutaka.

:: European Journal of Dermatology, 巻 16, 番号 3, 01.05.2006, p. 262-265.

研究成果: ジャーナルへの寄稿記事

Lin, N, Urabe, K, Moroi, Y, Hiroshi, U, Nakahara, T, Dainichi, T, Kokuba, H, Tu, Y & Furue, M 2006, 'Overexpression of phosphorylated-STAT3 and phosphorylated-ERK protein in dermatofibrosarcoma protuberans', European Journal of Dermatology, 巻. 16, 番号 3, pp. 262-265.
Lin, Nengxing ; Urabe, Kazunori ; Moroi, Yoichi ; Hiroshi, Uchi ; Nakahara, Takeshi ; Dainichi, Teruki ; Kokuba, Hisashi ; Tu, Yating ; Furue, Masutaka. / Overexpression of phosphorylated-STAT3 and phosphorylated-ERK protein in dermatofibrosarcoma protuberans. :: European Journal of Dermatology. 2006 ; 巻 16, 番号 3. pp. 262-265.
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abstract = "The overexpression of phosphorylated signal transducer and activator of transcription-3 (p-STAT3) and phosphorylated extracellular signal-regulated kinase (p-ERK) have recently been shown to play an important role in the pathogenesis of various human tumors. However, the role of these two major signal transduction pathways in dermatofibrosarcoma protuberans (DFSP) remains unknown. This study was designed to investigate the significance of p-STAT3 and p-ERK expression in DFSP. The expressions of p-STAT3 and p-ERK were analyzed by immunohistochemical staining in formalin-fixed, paraffin-embedded tissue sections of human DFSP and dermatofibroma. Ten cases were positive for p-STAT3 expression in 14 cases of DFSP, however, only 5 cases were positive in 20 cases of dermatofibroma. Eleven out of 14 cases of DFSP expressed p-ERK, but only four cases were positive in 20 cases of dermatofibroma. The expressions of p-STAT3 and p-ERK were significantly higher than those in dermatofibroma (both p < 0.01). This study suggests that the overexpression of p-STAT3 and p-ERK may play a pivotal role in the oncogenesis of DFSP.",
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AU - Lin, Nengxing

AU - Urabe, Kazunori

AU - Moroi, Yoichi

AU - Hiroshi, Uchi

AU - Nakahara, Takeshi

AU - Dainichi, Teruki

AU - Kokuba, Hisashi

AU - Tu, Yating

AU - Furue, Masutaka

PY - 2006/5/1

Y1 - 2006/5/1

N2 - The overexpression of phosphorylated signal transducer and activator of transcription-3 (p-STAT3) and phosphorylated extracellular signal-regulated kinase (p-ERK) have recently been shown to play an important role in the pathogenesis of various human tumors. However, the role of these two major signal transduction pathways in dermatofibrosarcoma protuberans (DFSP) remains unknown. This study was designed to investigate the significance of p-STAT3 and p-ERK expression in DFSP. The expressions of p-STAT3 and p-ERK were analyzed by immunohistochemical staining in formalin-fixed, paraffin-embedded tissue sections of human DFSP and dermatofibroma. Ten cases were positive for p-STAT3 expression in 14 cases of DFSP, however, only 5 cases were positive in 20 cases of dermatofibroma. Eleven out of 14 cases of DFSP expressed p-ERK, but only four cases were positive in 20 cases of dermatofibroma. The expressions of p-STAT3 and p-ERK were significantly higher than those in dermatofibroma (both p < 0.01). This study suggests that the overexpression of p-STAT3 and p-ERK may play a pivotal role in the oncogenesis of DFSP.

AB - The overexpression of phosphorylated signal transducer and activator of transcription-3 (p-STAT3) and phosphorylated extracellular signal-regulated kinase (p-ERK) have recently been shown to play an important role in the pathogenesis of various human tumors. However, the role of these two major signal transduction pathways in dermatofibrosarcoma protuberans (DFSP) remains unknown. This study was designed to investigate the significance of p-STAT3 and p-ERK expression in DFSP. The expressions of p-STAT3 and p-ERK were analyzed by immunohistochemical staining in formalin-fixed, paraffin-embedded tissue sections of human DFSP and dermatofibroma. Ten cases were positive for p-STAT3 expression in 14 cases of DFSP, however, only 5 cases were positive in 20 cases of dermatofibroma. Eleven out of 14 cases of DFSP expressed p-ERK, but only four cases were positive in 20 cases of dermatofibroma. The expressions of p-STAT3 and p-ERK were significantly higher than those in dermatofibroma (both p < 0.01). This study suggests that the overexpression of p-STAT3 and p-ERK may play a pivotal role in the oncogenesis of DFSP.

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