Overlapping and distinct signals through leptin receptor (OB-R) and a closely related cytokine signal transducer, gp130

Kinichi Nakashima, Masashi Narazaki, Tetsuya Taga

研究成果: ジャーナルへの寄稿学術誌査読

47 被引用数 (Scopus)

抄録

The structure of leptin receptor (OB-R) is highly homologous to that of gp130, the common signal transducing receptor component for the interleukin-6 family of cytokines. Based on this structural similarity, we examined signaling processes initiated by OB-R in comparison with those by gp130. Stimulation of either a long form of OB-R or gp130 led to tyrosine phosphorylation of STAT3, whereas stimulation of the truncated form of OB-R that is predominantly expressed in db/db mice failed to do so. Stimulation of the long form OB-R did not induce tyrosine phosphorylation of a Src homology domain 2 containing protein tyrosine phosphatase, SHP-2, while stimulation of gp130 did. In contrast, activation of p42(ERK2) is mediated by either the long form OB-R or gp130. Two closely related molecules, OB-R and gp130, thus appear to mediate overlapping but distinct signaling procedures.

本文言語英語
ページ(範囲)49-52
ページ数4
ジャーナルFEBS Letters
401
1
DOI
出版ステータス出版済み - 1月 13 1997
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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