Oxaliplatin induces hypomyelination and reduced neuregulin 1 expression in the rat sciatic nerve

Kuniaki Tsutsumi, Yuji Yamashita, Soichiro Ushio, takehiro kawashiri, Takanori Kaname, Shunsuke Fujita, Ryozo Oishi, Nobuaki Egashira

研究成果: ジャーナルへの寄稿記事

12 引用 (Scopus)

抄録

Oxaliplatin causes severe peripheral neuropathy. In this study, we examined hypomyelination in the peripheral nerve in oxaliplatin-induced neuropathy rat model. Gene expression of neuregulin 1 (NRG1), a myelination regulatory factor, is reduced in the dorsal root ganglion (DRG) in DNA microarray analysis. Oxaliplatin increased the g-ratio and reduced levels of myelin protein zero in sciatic nerve, suggesting the hypomyelination. Moreover, oxaliplatin reduced NRG1 mRNA levels in the DRG and decreased levels of cleaved NRG1 type III protein in the sciatic nerve. Our results indicate that oxaliplatin induces hypomyelination and reduced NRG1 expression.

元の言語英語
ページ(範囲)86-90
ページ数5
ジャーナルNeuroscience Research
80
発行部数1
DOI
出版物ステータス出版済み - 1 1 2014

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oxaliplatin
Neuregulin-1
Sciatic Nerve
Spinal Ganglia
Myelin P0 Protein
Peripheral Nervous System Diseases
Microarray Analysis
Oligonucleotide Array Sequence Analysis
Peripheral Nerves
Gene Expression
Messenger RNA

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

これを引用

Oxaliplatin induces hypomyelination and reduced neuregulin 1 expression in the rat sciatic nerve. / Tsutsumi, Kuniaki; Yamashita, Yuji; Ushio, Soichiro; kawashiri, takehiro; Kaname, Takanori; Fujita, Shunsuke; Oishi, Ryozo; Egashira, Nobuaki.

:: Neuroscience Research, 巻 80, 番号 1, 01.01.2014, p. 86-90.

研究成果: ジャーナルへの寄稿記事

Tsutsumi, Kuniaki ; Yamashita, Yuji ; Ushio, Soichiro ; kawashiri, takehiro ; Kaname, Takanori ; Fujita, Shunsuke ; Oishi, Ryozo ; Egashira, Nobuaki. / Oxaliplatin induces hypomyelination and reduced neuregulin 1 expression in the rat sciatic nerve. :: Neuroscience Research. 2014 ; 巻 80, 番号 1. pp. 86-90.
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abstract = "Oxaliplatin causes severe peripheral neuropathy. In this study, we examined hypomyelination in the peripheral nerve in oxaliplatin-induced neuropathy rat model. Gene expression of neuregulin 1 (NRG1), a myelination regulatory factor, is reduced in the dorsal root ganglion (DRG) in DNA microarray analysis. Oxaliplatin increased the g-ratio and reduced levels of myelin protein zero in sciatic nerve, suggesting the hypomyelination. Moreover, oxaliplatin reduced NRG1 mRNA levels in the DRG and decreased levels of cleaved NRG1 type III protein in the sciatic nerve. Our results indicate that oxaliplatin induces hypomyelination and reduced NRG1 expression.",
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AU - Tsutsumi, Kuniaki

AU - Yamashita, Yuji

AU - Ushio, Soichiro

AU - kawashiri, takehiro

AU - Kaname, Takanori

AU - Fujita, Shunsuke

AU - Oishi, Ryozo

AU - Egashira, Nobuaki

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N2 - Oxaliplatin causes severe peripheral neuropathy. In this study, we examined hypomyelination in the peripheral nerve in oxaliplatin-induced neuropathy rat model. Gene expression of neuregulin 1 (NRG1), a myelination regulatory factor, is reduced in the dorsal root ganglion (DRG) in DNA microarray analysis. Oxaliplatin increased the g-ratio and reduced levels of myelin protein zero in sciatic nerve, suggesting the hypomyelination. Moreover, oxaliplatin reduced NRG1 mRNA levels in the DRG and decreased levels of cleaved NRG1 type III protein in the sciatic nerve. Our results indicate that oxaliplatin induces hypomyelination and reduced NRG1 expression.

AB - Oxaliplatin causes severe peripheral neuropathy. In this study, we examined hypomyelination in the peripheral nerve in oxaliplatin-induced neuropathy rat model. Gene expression of neuregulin 1 (NRG1), a myelination regulatory factor, is reduced in the dorsal root ganglion (DRG) in DNA microarray analysis. Oxaliplatin increased the g-ratio and reduced levels of myelin protein zero in sciatic nerve, suggesting the hypomyelination. Moreover, oxaliplatin reduced NRG1 mRNA levels in the DRG and decreased levels of cleaved NRG1 type III protein in the sciatic nerve. Our results indicate that oxaliplatin induces hypomyelination and reduced NRG1 expression.

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