TY - JOUR
T1 - Oxidation of Guanosine Monophosphate with O2 via a Ru-peroxo Complex in Water
AU - Takenaka, Makoto
AU - Kikkawa, Mitsuhiro
AU - Matsumoto, Takahiro
AU - Yatabe, Takeshi
AU - Ando, Tatsuya
AU - Yoon, Ki Seok
AU - Ogo, Seiji
N1 - Funding Information:
This work was supported by JSPS KAKENHI Grant Numbers JP26000008 (Specially Promoted Research), JP18H02091, and JP16K05727 and the World Premier International Research Center Initiative (WPI), Japan.
Publisher Copyright:
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2018/11/2
Y1 - 2018/11/2
N2 - Oxidative damage of DNA by reactive oxygen species (ROS) is responsible for aging and cancer. Although many studies of DNA damage by ROS have been conducted, there have been no reports of the oxidation of RNA components, such as guanosine monophosphate, by metal-based species in water. Here, we report the first case of oxidation of guanosine monophosphate to 8-oxoguanosine monophosphate by a metal-based oxygen bound species, derived from O2 and in water.
AB - Oxidative damage of DNA by reactive oxygen species (ROS) is responsible for aging and cancer. Although many studies of DNA damage by ROS have been conducted, there have been no reports of the oxidation of RNA components, such as guanosine monophosphate, by metal-based species in water. Here, we report the first case of oxidation of guanosine monophosphate to 8-oxoguanosine monophosphate by a metal-based oxygen bound species, derived from O2 and in water.
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U2 - 10.1002/asia.201801267
DO - 10.1002/asia.201801267
M3 - Article
C2 - 30312012
AN - SCOPUS:85054853083
VL - 13
SP - 3180
EP - 3184
JO - Chemistry - An Asian Journal
JF - Chemistry - An Asian Journal
SN - 1861-4728
IS - 21
ER -
