Oxidation of Guanosine Monophosphate with O2 via a Ru-peroxo Complex in Water

Makoto Takenaka; Mitsuhiro Kikkawa; Takahiro Matsumoto; Takeshi Yatabe; Tatsuya Ando; Ki Seok Yoon; Seiji Ogo

doi:10.1002/asia.201801267

Oxidation of Guanosine Monophosphate with O₂ via a Ru-peroxo Complex in Water

Makoto Takenaka, Mitsuhiro Kikkawa, Takahiro Matsumoto, Takeshi Yatabe, Tatsuya Ando, Ki Seok Yoon, Seiji Ogo

研究成果: ジャーナルへの寄稿 › 記事

抜粋

Oxidative damage of DNA by reactive oxygen species (ROS) is responsible for aging and cancer. Although many studies of DNA damage by ROS have been conducted, there have been no reports of the oxidation of RNA components, such as guanosine monophosphate, by metal-based species in water. Here, we report the first case of oxidation of guanosine monophosphate to 8-oxoguanosine monophosphate by a metal-based oxygen bound species, derived from O₂ and in water.

元の言語	英語
ページ（範囲）	3180-3184
ページ数	5
ジャーナル	Chemistry - An Asian Journal
巻	13
発行部数	21
DOI	https://doi.org/10.1002/asia.201801267
出版物ステータス	出版済み - 11 2 2018

フィンガープリント

All Science Journal Classification (ASJC) codes

Biochemistry
Organic Chemistry

これを引用

Takenaka, M., Kikkawa, M., Matsumoto, T., Yatabe, T., Ando, T., Yoon, K. S., & Ogo, S. (2018). Oxidation of Guanosine Monophosphate with O₂ via a Ru-peroxo Complex in Water. Chemistry - An Asian Journal, 13(21), 3180-3184. https://doi.org/10.1002/asia.201801267

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AU - Ando, Tatsuya

AU - Yoon, Ki Seok

AU - Ogo, Seiji

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文献にアクセス

10.1002/asia.201801267