Oxidation of Guanosine Monophosphate with O 2 via a Ru-peroxo Complex in Water

研究成果: ジャーナルへの寄稿記事

抄録

Oxidative damage of DNA by reactive oxygen species (ROS) is responsible for aging and cancer. Although many studies of DNA damage by ROS have been conducted, there have been no reports of the oxidation of RNA components, such as guanosine monophosphate, by metal-based species in water. Here, we report the first case of oxidation of guanosine monophosphate to 8-oxoguanosine monophosphate by a metal-based oxygen bound species, derived from O 2 and in water.

元の言語英語
ページ(範囲)3180-3184
ページ数5
ジャーナルChemistry - An Asian Journal
13
発行部数21
DOI
出版物ステータス出版済み - 11 2 2018

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Guanosine Monophosphate
DNA Damage
Reactive Oxygen Species
Metals
Oxidation
Water
DNA
Aging of materials
RNA
Oxygen
Neoplasms
8-hydroxyguanosine

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry

これを引用

Oxidation of Guanosine Monophosphate with O 2 via a Ru-peroxo Complex in Water . / Takenaka, Makoto; Kikkawa, Mitsuhiro; Matsumoto, Takahiro; Yatabe, Takeshi; Ando, Tatsuya; Yoon, Ki Suk; Ogo, Seiji.

:: Chemistry - An Asian Journal, 巻 13, 番号 21, 02.11.2018, p. 3180-3184.

研究成果: ジャーナルへの寄稿記事

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AU - Yoon, Ki Suk

AU - Ogo, Seiji

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