抄録
Oxidative damage of DNA by reactive oxygen species (ROS) is responsible for aging and cancer. Although many studies of DNA damage by ROS have been conducted, there have been no reports of the oxidation of RNA components, such as guanosine monophosphate, by metal-based species in water. Here, we report the first case of oxidation of guanosine monophosphate to 8-oxoguanosine monophosphate by a metal-based oxygen bound species, derived from O 2 and in water.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 3180-3184 |
| ページ数 | 5 |
| ジャーナル | Chemistry - An Asian Journal |
| 巻 | 13 |
| 発行部数 | 21 |
| DOI | |
| 出版物ステータス | 出版済み - 11 2 2018 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Organic Chemistry
これを引用
Oxidation of Guanosine Monophosphate with O 2 via a Ru-peroxo Complex in Water . / Takenaka, Makoto; Kikkawa, Mitsuhiro; Matsumoto, Takahiro; Yatabe, Takeshi; Ando, Tatsuya; Yoon, Ki Suk; Ogo, Seiji.
：: Chemistry - An Asian Journal, 巻 13, 番号 21, 02.11.2018, p. 3180-3184.研究成果: ジャーナルへの寄稿 › 記事
}
TY - JOUR
T1 - Oxidation of Guanosine Monophosphate with O 2 via a Ru-peroxo Complex in Water
AU - Takenaka, Makoto
AU - Kikkawa, Mitsuhiro
AU - Matsumoto, Takahiro
AU - Yatabe, Takeshi
AU - Ando, Tatsuya
AU - Yoon, Ki Suk
AU - Ogo, Seiji
PY - 2018/11/2
Y1 - 2018/11/2
N2 - Oxidative damage of DNA by reactive oxygen species (ROS) is responsible for aging and cancer. Although many studies of DNA damage by ROS have been conducted, there have been no reports of the oxidation of RNA components, such as guanosine monophosphate, by metal-based species in water. Here, we report the first case of oxidation of guanosine monophosphate to 8-oxoguanosine monophosphate by a metal-based oxygen bound species, derived from O 2 and in water.
AB - Oxidative damage of DNA by reactive oxygen species (ROS) is responsible for aging and cancer. Although many studies of DNA damage by ROS have been conducted, there have been no reports of the oxidation of RNA components, such as guanosine monophosphate, by metal-based species in water. Here, we report the first case of oxidation of guanosine monophosphate to 8-oxoguanosine monophosphate by a metal-based oxygen bound species, derived from O 2 and in water.
UR - http://www.scopus.com/inward/record.url?scp=85054853083&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85054853083&partnerID=8YFLogxK
U2 - 10.1002/asia.201801267
DO - 10.1002/asia.201801267
M3 - Article
C2 - 30312012
AN - SCOPUS:85054853083
VL - 13
SP - 3180
EP - 3184
JO - Chemistry - An Asian Journal
JF - Chemistry - An Asian Journal
SN - 1861-4728
IS - 21
ER -