Oxidation of Guanosine Monophosphate with O2 via a Ru-peroxo Complex in Water

Makoto Takenaka, Mitsuhiro Kikkawa, Takahiro Matsumoto, Takeshi Yatabe, Tatsuya Ando, Ki Seok Yoon, Seiji Ogo

研究成果: Contribution to journalArticle査読

抄録

Oxidative damage of DNA by reactive oxygen species (ROS) is responsible for aging and cancer. Although many studies of DNA damage by ROS have been conducted, there have been no reports of the oxidation of RNA components, such as guanosine monophosphate, by metal-based species in water. Here, we report the first case of oxidation of guanosine monophosphate to 8-oxoguanosine monophosphate by a metal-based oxygen bound species, derived from O2 and in water.

本文言語英語
ページ(範囲)3180-3184
ページ数5
ジャーナルChemistry - An Asian Journal
13
21
DOI
出版ステータス出版済み - 11 2 2018

All Science Journal Classification (ASJC) codes

  • 生化学
  • 有機化学

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