Oxidative stress and androgen receptor signaling in the development and progression of castration-resistant prostate cancer

Masaki Shiota, Akira Yokomizo, Seiji Naito

研究成果: Contribution to journalReview article査読

77 被引用数 (Scopus)

抄録

Aberrant androgen receptor (AR) signaling plays a critical role in androgen-dependent prostate cancer (PCa), as well as in castration-resistant PCa (CRPC). Oxidative stress seems to contribute to the tumorigenesis and progression of PCa, as well as the development of CRPC, via activation of AR signaling. This notion is supported by the fact that there is an aberrant or improper regulation of the redox status in these disorders. Additionally, androgen-deprivation-induced oxidative stress seems to be involved in the pathogenesis of several disorders caused by androgen-deprivation therapy (ADT), including osteoporosis, neurodegenerative disease, and cardiovascular disease. Oxidative stress can be suppressed with antioxidants or via a reduction in reactive oxygen species production. Thus, developing new therapeutic agents that reduce oxidative stress might be useful in preventing the conversion of androgen-dependent PCa into CRPC, as well as reducing the adverse effects associated with ADT. The objective of this review is to provide an overview regarding the relationship between oxidative stress and AR signaling in the context of PCa and especially CRPC. Additionally, we discuss the potential use of antioxidant therapies in the treatment of PCa.

本文言語英語
ページ(範囲)1320-1328
ページ数9
ジャーナルFree Radical Biology and Medicine
51
7
DOI
出版ステータス出版済み - 10 1 2011

All Science Journal Classification (ASJC) codes

  • 生化学
  • 生理学(医学)

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