TY - JOUR
T1 - Oxidative stress and central cardiovascular regulation - Pathogenesis of hypertension and therapeutic aspects
AU - Hirooka, Yoshitaka
AU - Sagara, Yoji
AU - Kishi, Takuya
AU - Sunagawa, Kenji
N1 - Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.
PY - 2010
Y1 - 2010
N2 - Oxidative stress is a key factor in the pathogenesis of hypertension and target organ damage, beginning in the earliest stages. Extensive evidence indicates that the pivotal role of oxidative stress in the pathogenesis of hypertension is due to its effects on the vasculature in relation to the development of atherosclerotic processes. It remains unclear, however, whether oxidative stress in the brain, particularly the autonomic nuclei (including the vasomotor center), has an important role in the occurrence and maintenance of hypertension via activation of the sympathetic nervous system. The aim of the present review is to describe the contribution of oxidative stress in the brain to the neural mechanisms that underlie hypertension, and discuss evidence that brain oxidative stress is a potential therapeutic target.
AB - Oxidative stress is a key factor in the pathogenesis of hypertension and target organ damage, beginning in the earliest stages. Extensive evidence indicates that the pivotal role of oxidative stress in the pathogenesis of hypertension is due to its effects on the vasculature in relation to the development of atherosclerotic processes. It remains unclear, however, whether oxidative stress in the brain, particularly the autonomic nuclei (including the vasomotor center), has an important role in the occurrence and maintenance of hypertension via activation of the sympathetic nervous system. The aim of the present review is to describe the contribution of oxidative stress in the brain to the neural mechanisms that underlie hypertension, and discuss evidence that brain oxidative stress is a potential therapeutic target.
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U2 - 10.1253/circj.CJ-10-0153
DO - 10.1253/circj.CJ-10-0153
M3 - Review article
C2 - 20424336
AN - SCOPUS:77951760596
VL - 74
SP - 827
EP - 835
JO - Circulation Journal
JF - Circulation Journal
SN - 1346-9843
IS - 5
ER -