Oxidative stress and central cardiovascular regulation - Pathogenesis of hypertension and therapeutic aspects

Yoshitaka Hirooka, Yoji Sagara, Takuya Kishi, Kenji Sunagawa

    研究成果: Contribution to journalReview article査読

    90 被引用数 (Scopus)

    抄録

    Oxidative stress is a key factor in the pathogenesis of hypertension and target organ damage, beginning in the earliest stages. Extensive evidence indicates that the pivotal role of oxidative stress in the pathogenesis of hypertension is due to its effects on the vasculature in relation to the development of atherosclerotic processes. It remains unclear, however, whether oxidative stress in the brain, particularly the autonomic nuclei (including the vasomotor center), has an important role in the occurrence and maintenance of hypertension via activation of the sympathetic nervous system. The aim of the present review is to describe the contribution of oxidative stress in the brain to the neural mechanisms that underlie hypertension, and discuss evidence that brain oxidative stress is a potential therapeutic target.

    本文言語英語
    ページ(範囲)827-835
    ページ数9
    ジャーナルCirculation Journal
    74
    5
    DOI
    出版ステータス出版済み - 2010

    All Science Journal Classification (ASJC) codes

    • 循環器および心血管医学

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