p53 protein accumulation in multiple oesophageal squamous cell carcinoma: Relationship to risk factors

Hiroshi Saeki, Shinji Ohno, Mitsuhiro Miyazaki, Koshi Araki, Akinori Egashira, Hidetoshi Kawaguchi, Masayuki Watanabe, Masaru Morita, Keizo Sugimachi

研究成果: ジャーナルへの寄稿記事

21 引用 (Scopus)

抄録

To clarify mechanisms involved in the carcinogenesis of multiple oesophageal squamous cell carcinoma, the expression of p53 protein in 46 lesions surgically excised from 13 Japanese patients was investigated immunohistochemically and the relation of p53 protein accumulation to the patient's history of alcohol consumption and cigarette smoking was analyzed. p53 protein accumulation was observed in 13 main lesions, that is in 6 (85.7%) of 7 subjects with a history of heavy drinking and smoking, but only in 1 (16.7%) of 6 with no such history (Fisher's exact test, p = 0.025). As regards the 46 lesions, p53 protein accumulation was evident in 22 (88.0%) of 25 lesions of the high-risk patients, but in 7 (33.3%) of 21 lesions of the other subjects (Fisher's exact test, p < 0.001). p53 protein accumulation was similarly recognized in all oesophageal lesions in 5 of 7 high-risk patients. Thus, use of both alcohol and cigarettes is clearly associated with a high frequency of p53 protein accumulation in multiple oesophageal squamous cell carcinoma present at the same time. These findings are considered to support the concept of field carcinogenesis of the oesophagus.

元の言語英語
ページ(範囲)175-179
ページ数5
ジャーナルOncology
62
発行部数2
DOI
出版物ステータス出版済み - 4 6 2002

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Proteins
Carcinogenesis
Smoking
Tobacco Products
Alcohol Drinking
Esophagus
Drinking
Esophageal Squamous Cell Carcinoma
History
Alcohols

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Saeki, H., Ohno, S., Miyazaki, M., Araki, K., Egashira, A., Kawaguchi, H., ... Sugimachi, K. (2002). p53 protein accumulation in multiple oesophageal squamous cell carcinoma: Relationship to risk factors. Oncology, 62(2), 175-179. https://doi.org/10.1159/000048264

p53 protein accumulation in multiple oesophageal squamous cell carcinoma : Relationship to risk factors. / Saeki, Hiroshi; Ohno, Shinji; Miyazaki, Mitsuhiro; Araki, Koshi; Egashira, Akinori; Kawaguchi, Hidetoshi; Watanabe, Masayuki; Morita, Masaru; Sugimachi, Keizo.

:: Oncology, 巻 62, 番号 2, 06.04.2002, p. 175-179.

研究成果: ジャーナルへの寄稿記事

Saeki, H, Ohno, S, Miyazaki, M, Araki, K, Egashira, A, Kawaguchi, H, Watanabe, M, Morita, M & Sugimachi, K 2002, 'p53 protein accumulation in multiple oesophageal squamous cell carcinoma: Relationship to risk factors', Oncology, 巻. 62, 番号 2, pp. 175-179. https://doi.org/10.1159/000048264
Saeki H, Ohno S, Miyazaki M, Araki K, Egashira A, Kawaguchi H その他. p53 protein accumulation in multiple oesophageal squamous cell carcinoma: Relationship to risk factors. Oncology. 2002 4 6;62(2):175-179. https://doi.org/10.1159/000048264
Saeki, Hiroshi ; Ohno, Shinji ; Miyazaki, Mitsuhiro ; Araki, Koshi ; Egashira, Akinori ; Kawaguchi, Hidetoshi ; Watanabe, Masayuki ; Morita, Masaru ; Sugimachi, Keizo. / p53 protein accumulation in multiple oesophageal squamous cell carcinoma : Relationship to risk factors. :: Oncology. 2002 ; 巻 62, 番号 2. pp. 175-179.
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