p97/p47-mediated biogenesis of Golgi and ER

Keiji Uchiyama, Hisao Kondo

研究成果: ジャーナルへの寄稿小調査

80 引用 (Scopus)

抄録

In mammalian cells, the Golgi apparatus and endoplasmic reticulum have typical structures during interphase: stacked cisternae located adjacent to the nucleus and a network of interconnected tubules throughout the cytoplasm, respectively. At mitosis their architectures disappear and are reassembled in daughter cells. p97, an AAA-ATPase, mediates membrane fusion and is required for reassembly of these organelles. In the p97-mediated membrane fusion, p47 was identified as an essential cofactor, through which p97 binds to a SNARE, syntaxin5. A second essential cofactor, VCIP135, was identified as a p97/p47/syntaxin5-interacting protein. Several lines of recent evidence suggest that ubiquitination may be implicated in the p97/p47 pathway; p47 binds to monoubiquitinated proteins and VCIP135 shows a deubiquitinating activity in vitro. For the cell-cycle regulation of the p97/p47 pathway, it has been reported that the localization and phosphorylation-dephosphorylation of p47 are crucial. In this review, we describe the components involved in the p97-mediated membrane fusion and discuss the regulation of the fusion pathway.

元の言語英語
ページ(範囲)115-119
ページ数5
ジャーナルJournal of Biochemistry
137
発行部数2
DOI
出版物ステータス出版済み - 2 2005
外部発表Yes

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Membrane Fusion
Fusion reactions
Membranes
SNARE Proteins
Ubiquitination
Interphase
Cells
Golgi Apparatus
Mitosis
Endoplasmic Reticulum
Organelles
Phosphorylation
Cell Cycle
Cytoplasm
Proteins
Adenosine Triphosphatases

All Science Journal Classification (ASJC) codes

  • Biochemistry

これを引用

p97/p47-mediated biogenesis of Golgi and ER. / Uchiyama, Keiji; Kondo, Hisao.

:: Journal of Biochemistry, 巻 137, 番号 2, 02.2005, p. 115-119.

研究成果: ジャーナルへの寄稿小調査

Uchiyama, Keiji ; Kondo, Hisao. / p97/p47-mediated biogenesis of Golgi and ER. :: Journal of Biochemistry. 2005 ; 巻 137, 番号 2. pp. 115-119.
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