Paired box 7 inhibits differentiation in 3T3-L1 preadipocytes

Wakana Izumi, Yuko Takuma, Ryo Ebihara, Wataru Mizunoya, Ryuichi Tatsumi, Mako Nakamura

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

抄録

Myogenesis is precisely proceeded by myogenic regulatory factors. Myogenic stem cells are activated, proliferated and fused into a multinuclear myofiber. Pax7, paired box 7, one of the earliest markers during myogenesis. It has been reported that Pax7 regulates the muscle marker genes, Myf5 and MyoD toward differentiation. The possible roles of Pax7 in myogenic cells have been well researched. However, it has not yet been clarified if Pax7 itself is able to induce myogenic fate in nonmyogenic lineage cells. In this study, we performed experiments using stably expressed Pax7 in 3T3-L1 preadipocytes to elucidate if Pax7 inhibits adipogenesis. We found that Pax7 represses adipogenic markers and prevents differentiation. These cells showed decreased expression of PDGFRα, PPARγ and Fabp4 and inhibited forming lipid droplets.

元の言語英語
ページ(範囲)1214-1219
ページ数6
ジャーナルAnimal Science Journal
89
発行部数8
DOI
出版物ステータス出版済み - 8 1 2018

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Muscle Development
muscle development
Myogenic Regulatory Factors
Adipogenesis
Peroxisome Proliferator-Activated Receptors
Differentiation Antigens
cells
droplets
stem cells
Stem Cells
Muscles
muscles
genetic markers
lipids
Genes
Lipid Droplets
adipogenesis
myogenic regulatory factors

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences(all)

これを引用

Paired box 7 inhibits differentiation in 3T3-L1 preadipocytes. / Izumi, Wakana; Takuma, Yuko; Ebihara, Ryo; Mizunoya, Wataru; Tatsumi, Ryuichi; Nakamura, Mako.

:: Animal Science Journal, 巻 89, 番号 8, 01.08.2018, p. 1214-1219.

研究成果: ジャーナルへの寄稿記事

Izumi, Wakana ; Takuma, Yuko ; Ebihara, Ryo ; Mizunoya, Wataru ; Tatsumi, Ryuichi ; Nakamura, Mako. / Paired box 7 inhibits differentiation in 3T3-L1 preadipocytes. :: Animal Science Journal. 2018 ; 巻 89, 番号 8. pp. 1214-1219.
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AU - Nakamura, Mako

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