Paired box 7 inhibits differentiation in 3T3-L1 preadipocytes

Wakana Izumi, Yuko Takuma, Ryo Ebihara, Wataru Mizunoya, Ryuichi Tatsumi, Mako Nakamura

研究成果: Contribution to journalArticle査読

2 被引用数 (Scopus)

抄録

Myogenesis is precisely proceeded by myogenic regulatory factors. Myogenic stem cells are activated, proliferated and fused into a multinuclear myofiber. Pax7, paired box 7, one of the earliest markers during myogenesis. It has been reported that Pax7 regulates the muscle marker genes, Myf5 and MyoD toward differentiation. The possible roles of Pax7 in myogenic cells have been well researched. However, it has not yet been clarified if Pax7 itself is able to induce myogenic fate in nonmyogenic lineage cells. In this study, we performed experiments using stably expressed Pax7 in 3T3-L1 preadipocytes to elucidate if Pax7 inhibits adipogenesis. We found that Pax7 represses adipogenic markers and prevents differentiation. These cells showed decreased expression of PDGFRα, PPARγ and Fabp4 and inhibited forming lipid droplets.

本文言語英語
ページ(範囲)1214-1219
ページ数6
ジャーナルAnimal Science Journal
89
8
DOI
出版ステータス出版済み - 8 2018

All Science Journal Classification (ASJC) codes

  • 農業および生物科学(全般)

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