Palladium-catalyzed direct C-H silylation and germanylation of benzamides and carboxamides

Kyalo Stephen Kanyiva, Yoichiro Kuninobu, Motomu Kanai

研究成果: Contribution to journalArticle査読

86 被引用数 (Scopus)

抄録

A palladium-catalyzed regioselective activation of C(sp2)-H and C(sp3)-H bonds of benzamides and carboxamides, followed by coupling with disilanes to afford organosilanes in moderate to high yields, with the aid of 8-aminoquinoline as a directing group, is reported. Catalytic C(sp 2)-H germanylation of benzamides also proceeds under the same palladium catalysis. The reaction tolerates a wide variety of functional groups and is scalable without yield reduction. The bidentate directing group is readily removed and recovered by the reaction with a hydrazine, with concominant generation of an acyl hydrazide.

本文言語英語
ページ(範囲)1968-1971
ページ数4
ジャーナルOrganic letters
16
7
DOI
出版ステータス出版済み - 4 4 2014
外部発表はい

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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