Palladium-catalyzed synthesis of a phosphine oxide with a chiral phosphorus center via C-H phosphination

Yoichiro Kuninobu, Kazuki Origuchi, Kazuhiko Takai

研究成果: Contribution to journalArticle

13 引用 (Scopus)

抜粋

A new phosphine oxide with a chiral phosphine center was synthesized from a bis(biphenyl)phosphine oxide by dehydrogenative intramolecular cyclization via P-H and C-H bond activation under palladium catalysis. The absolute configuration of one enantiomer of the phosphine oxide was determined by single crystal X-ray structure analysis. By reducing the phosphine oxide, the corresponding phosphine, which also has a chiral center, was produced. The phosphine compounds could be optically resolved by chiral HPLC column chromatography.

元の言語英語
ページ(範囲)3029-3034
ページ数6
ジャーナルHeterocycles
85
発行部数12
DOI
出版物ステータス出版済み - 12 4 2012
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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