Paraneoplastic brainstem encephalitis and subacute sensory neuropathy presenting various neurological symptoms associated with small cell lung cancer

Kyoko Kudo, Miiru Izumi, Koichi Takayama, Satoru Fukuyama, Kentaro Tanaka, Yoichi Nakanishi

研究成果: ジャーナルへの寄稿記事

抄録

Background. Paraneoplastic brainstem encephalitis and subacute sensory neuropathy are included in paraneoplastic neurological syndrome (PNS) and are rarely accompanied by small cell lung cancer. PNS is often difficult to diagnose or to treat them. Case. A 71 year-old man presented with syncope, diplopia, blepharoptosis and dysphagia and was admitted to our hospital. Brain MRI was normal. Chest CT showed mediastinal lymphadenopathy. The lymph node biopsy yielded a diagnosis of small cell lung cancer (cT4N2M0, stage IIIB). And as for the neurological symptoms, the presence of a serum anti-Hu antibody supported the diagnosis of paraneoplastic brainstem encephalitis and subacute sensory neuropathy. Platinum-based chemotherapy resulted in partial response but the neurological symptoms deteriorated. Conclusion. We reported a case of paraneoplastic brainstem encephalitis and subacute sensory neuropathy accompanied by small cell lung cancer. There are vari-ous types of paraneoplastic neurological syndrome, and further studies for the treatment of each neurological symptom are required.

元の言語英語
ページ(範囲)852-856
ページ数5
ジャーナルJapanese Journal of Lung Cancer
49
発行部数6
DOI
出版物ステータス出版済み - 10 1 2009

Fingerprint

Paraneoplastic Syndromes
Small Cell Lung Carcinoma
Encephalitis
Brain Stem
Blepharoptosis
Diplopia
Syncope
Deglutition Disorders
Platinum
Anti-Idiotypic Antibodies
Thorax
Lymph Nodes
Biopsy
Drug Therapy
Brain
Serum
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pulmonary and Respiratory Medicine

これを引用

Paraneoplastic brainstem encephalitis and subacute sensory neuropathy presenting various neurological symptoms associated with small cell lung cancer. / Kudo, Kyoko; Izumi, Miiru; Takayama, Koichi; Fukuyama, Satoru; Tanaka, Kentaro; Nakanishi, Yoichi.

:: Japanese Journal of Lung Cancer, 巻 49, 番号 6, 01.10.2009, p. 852-856.

研究成果: ジャーナルへの寄稿記事

@article{0150c59543f04b90b74a375f535eee53,
title = "Paraneoplastic brainstem encephalitis and subacute sensory neuropathy presenting various neurological symptoms associated with small cell lung cancer",
abstract = "Background. Paraneoplastic brainstem encephalitis and subacute sensory neuropathy are included in paraneoplastic neurological syndrome (PNS) and are rarely accompanied by small cell lung cancer. PNS is often difficult to diagnose or to treat them. Case. A 71 year-old man presented with syncope, diplopia, blepharoptosis and dysphagia and was admitted to our hospital. Brain MRI was normal. Chest CT showed mediastinal lymphadenopathy. The lymph node biopsy yielded a diagnosis of small cell lung cancer (cT4N2M0, stage IIIB). And as for the neurological symptoms, the presence of a serum anti-Hu antibody supported the diagnosis of paraneoplastic brainstem encephalitis and subacute sensory neuropathy. Platinum-based chemotherapy resulted in partial response but the neurological symptoms deteriorated. Conclusion. We reported a case of paraneoplastic brainstem encephalitis and subacute sensory neuropathy accompanied by small cell lung cancer. There are vari-ous types of paraneoplastic neurological syndrome, and further studies for the treatment of each neurological symptom are required.",
author = "Kyoko Kudo and Miiru Izumi and Koichi Takayama and Satoru Fukuyama and Kentaro Tanaka and Yoichi Nakanishi",
year = "2009",
month = "10",
day = "1",
doi = "10.2482/haigan.49.852",
language = "English",
volume = "49",
pages = "852--856",
journal = "Japanese Journal of Lung Cancer",
issn = "0386-9628",
publisher = "Japan Lung Cancer Society",
number = "6",

}

TY - JOUR

T1 - Paraneoplastic brainstem encephalitis and subacute sensory neuropathy presenting various neurological symptoms associated with small cell lung cancer

AU - Kudo, Kyoko

AU - Izumi, Miiru

AU - Takayama, Koichi

AU - Fukuyama, Satoru

AU - Tanaka, Kentaro

AU - Nakanishi, Yoichi

PY - 2009/10/1

Y1 - 2009/10/1

N2 - Background. Paraneoplastic brainstem encephalitis and subacute sensory neuropathy are included in paraneoplastic neurological syndrome (PNS) and are rarely accompanied by small cell lung cancer. PNS is often difficult to diagnose or to treat them. Case. A 71 year-old man presented with syncope, diplopia, blepharoptosis and dysphagia and was admitted to our hospital. Brain MRI was normal. Chest CT showed mediastinal lymphadenopathy. The lymph node biopsy yielded a diagnosis of small cell lung cancer (cT4N2M0, stage IIIB). And as for the neurological symptoms, the presence of a serum anti-Hu antibody supported the diagnosis of paraneoplastic brainstem encephalitis and subacute sensory neuropathy. Platinum-based chemotherapy resulted in partial response but the neurological symptoms deteriorated. Conclusion. We reported a case of paraneoplastic brainstem encephalitis and subacute sensory neuropathy accompanied by small cell lung cancer. There are vari-ous types of paraneoplastic neurological syndrome, and further studies for the treatment of each neurological symptom are required.

AB - Background. Paraneoplastic brainstem encephalitis and subacute sensory neuropathy are included in paraneoplastic neurological syndrome (PNS) and are rarely accompanied by small cell lung cancer. PNS is often difficult to diagnose or to treat them. Case. A 71 year-old man presented with syncope, diplopia, blepharoptosis and dysphagia and was admitted to our hospital. Brain MRI was normal. Chest CT showed mediastinal lymphadenopathy. The lymph node biopsy yielded a diagnosis of small cell lung cancer (cT4N2M0, stage IIIB). And as for the neurological symptoms, the presence of a serum anti-Hu antibody supported the diagnosis of paraneoplastic brainstem encephalitis and subacute sensory neuropathy. Platinum-based chemotherapy resulted in partial response but the neurological symptoms deteriorated. Conclusion. We reported a case of paraneoplastic brainstem encephalitis and subacute sensory neuropathy accompanied by small cell lung cancer. There are vari-ous types of paraneoplastic neurological syndrome, and further studies for the treatment of each neurological symptom are required.

UR - http://www.scopus.com/inward/record.url?scp=73649131574&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=73649131574&partnerID=8YFLogxK

U2 - 10.2482/haigan.49.852

DO - 10.2482/haigan.49.852

M3 - Article

VL - 49

SP - 852

EP - 856

JO - Japanese Journal of Lung Cancer

JF - Japanese Journal of Lung Cancer

SN - 0386-9628

IS - 6

ER -