TY - JOUR
T1 - Parvovirus B19-infected tubulointerstitial nephritis in hereditary spherocytosis
AU - Nishiyama, Kei
AU - Watanabe, Yuka
AU - Ishimura, Masataka
AU - Tetsuhara, Kenichi
AU - Imai, Takashi
AU - Kanemasa, Hikaru
AU - Ueki, Kenji
AU - Motomura, Yoshitomo
AU - Kaku, Noriyuki
AU - Sakai, Yasunari
AU - Imadome, Ken Ichi
AU - Ohga, Shouichi
N1 - Funding Information:
Disclaimer. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Financial support. This study was funded by the Morinaga Foundation for Health and Nutrition. Potential conflicts of interest. All authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest.
Funding Information:
We thank Dr. Tamami Tanaka (Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University) for performing the cell sorting using flow cytometry, Katsuhiko Miki (Advanced Technology and Developmental Division, BML, Inc.) for performing polymerase chain reaction for parvovirus B19 deoxyribonucleic acid, Mikio Munakata (Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University) for technical assistance, and Drs. Etsuro Nanishi and Yuuki Iwaya (Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University) for treatment and helpful discussion, along with all of the staff who treated the patients in Kyushu University Hospital. This study was funded by the Morinaga Foundation for Health and Nutrition.
Publisher Copyright:
© The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
PY - 2020/8/1
Y1 - 2020/8/1
N2 - Background. Human parvovirus B19 (B19V) causes glomerulopathy or microangiopathy, but not tubulopathy. We experienced an 11-year-old girl with spherocytosis who developed acute kidney injury on a primary infection of B19V. She presented with anuria, encephalopathy, thrombocytopenia, and coagulopathy, along with no apparent aplastic crisis. Methods. Continuous hemodiafiltration, immunoglobulin, and intensive therapies led to a cure. Results. A kidney biopsy resulted in a histopathological diagnosis of tubulointerstitial nephritis without immune deposits. The virus capsid protein was limitedly expressed in the tubular epithelial cells with infiltrating CD8-positive cells. Conclusions. Viral and histopathological analyses first demonstrated B19-infected tubulointerstitial nephritis due to the aberrant viremia with hereditary spherocytosis.
AB - Background. Human parvovirus B19 (B19V) causes glomerulopathy or microangiopathy, but not tubulopathy. We experienced an 11-year-old girl with spherocytosis who developed acute kidney injury on a primary infection of B19V. She presented with anuria, encephalopathy, thrombocytopenia, and coagulopathy, along with no apparent aplastic crisis. Methods. Continuous hemodiafiltration, immunoglobulin, and intensive therapies led to a cure. Results. A kidney biopsy resulted in a histopathological diagnosis of tubulointerstitial nephritis without immune deposits. The virus capsid protein was limitedly expressed in the tubular epithelial cells with infiltrating CD8-positive cells. Conclusions. Viral and histopathological analyses first demonstrated B19-infected tubulointerstitial nephritis due to the aberrant viremia with hereditary spherocytosis.
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U2 - 10.1093/ofid/ofaa288
DO - 10.1093/ofid/ofaa288
M3 - Article
AN - SCOPUS:85092115502
VL - 7
JO - Open Forum Infectious Diseases
JF - Open Forum Infectious Diseases
SN - 2328-8957
IS - 8
M1 - ofaa288
ER -