TY - JOUR
T1 - Parvovirus B19-infected tubulointerstitial nephritis in hereditary spherocytosis
AU - Nishiyama, Kei
AU - Watanabe, Yuka
AU - Ishimura, Masataka
AU - Tetsuhara, Kenichi
AU - Imai, Takashi
AU - Kanemasa, Hikaru
AU - Ueki, Kenji
AU - Motomura, Yoshitomo
AU - Kaku, Noriyuki
AU - Sakai, Yasunari
AU - Imadome, Ken Ichi
AU - Ohga, Shouichi
N1 - Funding Information:
Disclaimer. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Financial support. This study was funded by the Morinaga Foundation for Health and Nutrition. Potential conflicts of interest. All authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest.
PY - 2020/8/1
Y1 - 2020/8/1
N2 - Background. Human parvovirus B19 (B19V) causes glomerulopathy or microangiopathy, but not tubulopathy. We experienced an 11-year-old girl with spherocytosis who developed acute kidney injury on a primary infection of B19V. She presented with anuria, encephalopathy, thrombocytopenia, and coagulopathy, along with no apparent aplastic crisis. Methods. Continuous hemodiafiltration, immunoglobulin, and intensive therapies led to a cure. Results. A kidney biopsy resulted in a histopathological diagnosis of tubulointerstitial nephritis without immune deposits. The virus capsid protein was limitedly expressed in the tubular epithelial cells with infiltrating CD8-positive cells. Conclusions. Viral and histopathological analyses first demonstrated B19-infected tubulointerstitial nephritis due to the aberrant viremia with hereditary spherocytosis.
AB - Background. Human parvovirus B19 (B19V) causes glomerulopathy or microangiopathy, but not tubulopathy. We experienced an 11-year-old girl with spherocytosis who developed acute kidney injury on a primary infection of B19V. She presented with anuria, encephalopathy, thrombocytopenia, and coagulopathy, along with no apparent aplastic crisis. Methods. Continuous hemodiafiltration, immunoglobulin, and intensive therapies led to a cure. Results. A kidney biopsy resulted in a histopathological diagnosis of tubulointerstitial nephritis without immune deposits. The virus capsid protein was limitedly expressed in the tubular epithelial cells with infiltrating CD8-positive cells. Conclusions. Viral and histopathological analyses first demonstrated B19-infected tubulointerstitial nephritis due to the aberrant viremia with hereditary spherocytosis.
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U2 - 10.1093/ofid/ofaa288
DO - 10.1093/ofid/ofaa288
M3 - Article
AN - SCOPUS:85092115502
VL - 7
JO - Open Forum Infectious Diseases
JF - Open Forum Infectious Diseases
SN - 2328-8957
IS - 8
M1 - ofaa288
ER -