Parvovirus B19-infected tubulointerstitial nephritis in hereditary spherocytosis

Kei Nishiyama, Yuka Watanabe, Masataka Ishimura, Kenichi Tetsuhara, Takashi Imai, Hikaru Kanemasa, Kenji Ueki, Yoshitomo Motomura, Noriyuki Kaku, Yasunari Sakai, Ken Ichi Imadome, Shouichi Ohga

研究成果: Contribution to journalArticle査読

抄録

Background. Human parvovirus B19 (B19V) causes glomerulopathy or microangiopathy, but not tubulopathy. We experienced an 11-year-old girl with spherocytosis who developed acute kidney injury on a primary infection of B19V. She presented with anuria, encephalopathy, thrombocytopenia, and coagulopathy, along with no apparent aplastic crisis. Methods. Continuous hemodiafiltration, immunoglobulin, and intensive therapies led to a cure. Results. A kidney biopsy resulted in a histopathological diagnosis of tubulointerstitial nephritis without immune deposits. The virus capsid protein was limitedly expressed in the tubular epithelial cells with infiltrating CD8-positive cells. Conclusions. Viral and histopathological analyses first demonstrated B19-infected tubulointerstitial nephritis due to the aberrant viremia with hereditary spherocytosis.

本文言語英語
論文番号ofaa288
ジャーナルOpen Forum Infectious Diseases
7
8
DOI
出版ステータス出版済み - 8 1 2020

All Science Journal Classification (ASJC) codes

  • Oncology
  • Clinical Neurology

フィンガープリント 「Parvovirus B19-infected tubulointerstitial nephritis in hereditary spherocytosis」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル