Passive immunization with bovine milk containing antibodies to a cell surface protein antigen-glucosyltransferase fusion protein protects rats against dental caries

Morihide Mitoma, Takahiko Oho, Naoko Michibata, Kaoru Okano, Yutaka Nakano, Masataka Fukuyama, Toshihiko Koga

研究成果: ジャーナルへの寄稿記事

19 引用 (Scopus)

抄録

Cell surface protein antigen (PAc) and glucosyltransferases (GTF) of Streptococcus mutans are major colonization factors of the organism. We prepared bovine milk containing antibodies against a fusion of the saliva-binding alanine-rich region of PAc with the glucan-binding domain of GTF-I. This study examined the effect of the immune milk on the cariogenicity of S. mutans in a rat model. Concentrated immune milk was fed to rats once a day for 55 days. The group that received immune milk had significantly less caries development than controls.

元の言語英語
ページ(範囲)2721-2724
ページ数4
ジャーナルInfection and Immunity
70
発行部数5
DOI
出版物ステータス出版済み - 4 29 2002

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Glucosyltransferases
Passive Immunization
Dental Caries
Surface Antigens
Membrane Proteins
Milk
Streptococcus mutans
Antibodies
Proteins
Glucans
Saliva
Alanine

All Science Journal Classification (ASJC) codes

  • Immunology

これを引用

Passive immunization with bovine milk containing antibodies to a cell surface protein antigen-glucosyltransferase fusion protein protects rats against dental caries. / Mitoma, Morihide; Oho, Takahiko; Michibata, Naoko; Okano, Kaoru; Nakano, Yutaka; Fukuyama, Masataka; Koga, Toshihiko.

:: Infection and Immunity, 巻 70, 番号 5, 29.04.2002, p. 2721-2724.

研究成果: ジャーナルへの寄稿記事

Mitoma, Morihide ; Oho, Takahiko ; Michibata, Naoko ; Okano, Kaoru ; Nakano, Yutaka ; Fukuyama, Masataka ; Koga, Toshihiko. / Passive immunization with bovine milk containing antibodies to a cell surface protein antigen-glucosyltransferase fusion protein protects rats against dental caries. :: Infection and Immunity. 2002 ; 巻 70, 番号 5. pp. 2721-2724.
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