Pathogenesis of giant somatosensory evoked potentials in progressive myoclonic epilepsy

Hiroshi Shibasaki, Yoriaki Yamashita, Ryuji Neshige, Shozo Tobimatsu, Ritsuko Fukui

研究成果: ジャーナルへの寄稿学術誌査読

233 被引用数 (Scopus)


Fifty-seven consecutive patients with myoclonus from various causes were studied by electrophysio-logical techniques. Giant somatosensory evoked potentials (SEPs) were observed almost exclusively in patients with progressive myoclonic epilepsy (PME) and diseases with similar clinical features that included lipidosis, neuronal ceroid lipofuscinosis and posthypoxic myoclonus. On the basis of combinations of the giant SEP and the myoclonus-related cortical spike demonstrated by jerk-locked averaging, myoclonus in these patients was classified into four types. In patients with 'cortical' reflex' myoclonus (type I) who showed both the giant SEP and the myoclonus-related cortical spike, these two cortical activities were similar in terms of wave form, scalp topography, time relationship to either the long latency (C) reflex or myoclonus, the following cortical excitability, the effect of antimyoclonus drugs and alterations during slow wave sleep. It is therefore postulated that the giant SEP is generated, at least in part, by common physiological mechanisms to the myoclonus-related cortical spike, or that the latter may comprise a constituent of the former. In most patients with PME or allied diseases, both afferent and efferent components of the SEP are enhanced, but in some patients, only one of the two components seems to be predominantly enhanced.

出版ステータス出版済み - 3月 1 1985

!!!All Science Journal Classification (ASJC) codes

  • 臨床神経学


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