Pathogenesis of Vibrio parahaemolyticus: Intraperitoneal and Orogastric Challenge Experiments in Mice

Kikuo Hoashi, Hatsumi Taniguchi, Hiroto Yamashita, Koichi Tsuji, Kikuyo Ogata, Yasuo Mizuguchi, Nobuya Ohtomo

研究成果: Contribution to journalArticle査読

25 被引用数 (Scopus)

抄録

It has been noted that V. parahaemolyticus isolated from patients with food poisoning are almost always thermostable direct hemolysin (TDH)-positive, whereas, isolates from foods or environmental sources are usually TDH-negative. The virulence of V. parahaemolyticus in mice was examined by using intraperitoneal and orogastric challenge models, where the strains used were those isolated from patients and foods with food poisoning and included TDH-positive and -negative. The LD50 in mice was estimated to be approximately 107 in the former and 108 in the latter challenge model. In the mice killed by challenge, either intraperitoneal or orogastric, the following pathological changes were almost always observed: swelling, redness and fluid accumulation in the small intestine, particularly the upper part of it. Histologically, congestion, edema, and vacuolation were observed in mucosal and submucosal tissues; furthermore, ulceration at tips of some villi was noticed. The lethality and pathological finding in mice due to V. parahaemolyticus were demonstrated similarly in both challenge models and irrespective of the TDH phenotype of the strain used. It will be suggested that the findings in challenged mice may be attributed to enteropathogenic factor(s) other than TDH of V. parahaemolyticus.

本文言語英語
ページ(範囲)355-366
ページ数12
ジャーナルMICROBIOLOGY and IMMUNOLOGY
34
4
DOI
出版ステータス出版済み - 1990
外部発表はい

All Science Journal Classification (ASJC) codes

  • 微生物学
  • 免疫学
  • ウイルス学

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