Pathogenic implication of epidermal scratch injury in psoriasis and atopic dermatitis

Kazuhisa Furue, Dugarmaa Ulzii, Yuka Tanaka, Takamichi Ito, Gaku Tsuji, Makiko Kido-Nakahara, Takeshi Nakahara, Masutaka Furue

研究成果: Contribution to journalReview article査読

抄録

Mechanical scratching, a common external stress affecting the skin, is induced by various causes, such as pruritus. Scratch injury to epidermal keratinocytes upregulates the production and release of chemokine (C-C motif) ligand 20 (CCL20) in vitro, which selectively chemoattracts interleukin (IL)-17A-producing immune cells that express chemokine (C-C motif) receptor 6 (CCR6). In IL-17A-dominant psoriasis, scratch-induced CCL20 upregulation and subsequent accumulation of IL-17A-producing immune cells and CCR6+ mature dendritic cells may trigger the development of psoriatic lesions, a process known as the Koebner phenomenon. In IL-4/IL-13-dominant atopic dermatitis, pruritus and subsequent scratching are the primary symptoms. Scratch-induced CCL20 production from keratinocytes may explain why IL-17A levels are also elevated in atopic dermatitis. In contrast, mechanical scratching is likely to negatively regulate IL-13 signaling by upregulating the expression of IL-13 receptor α2, which serves as a decoy receptor for IL-13 in keratinocytes. In this review, we summarize current reports on topics related to the pathogenic role of epidermal scratch injury in psoriasis and atopic dermatitis.

本文言語英語
ページ(範囲)979-988
ページ数10
ジャーナルJournal of Dermatology
47
9
DOI
出版ステータス出版済み - 9 1 2020

All Science Journal Classification (ASJC) codes

  • Dermatology

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