Pathology and significance of leptin resistance in obesity

S. Hidaka, Y. Ogawa, K. Ebihara, M. Shintani, M. Abe, F. Miyanaga, K. Nakao

研究成果: Contribution to journalReview article査読

2 被引用数 (Scopus)

抄録

Leptin, the protein product of the ob gene, is predominantly secreted from white adipose tissue, and acts on the brain to regulate food intake, energy expenditure, and neuroendocrine function. Obese rodent and humans are mostly associated with high circulating leptin levels. These findings have led to the conclusion that obese individuals are relatively insensitive to endogenous leptin termed 'leptin resistance'. The potential sites for leptin resistance include the blood-brain-barrier transport system and the leptin signaling mechanism in leptin-responsive neurons in the hypothalamus. In this review, we describe leptin, leptin receptor, and potential hypothesis of leptin resistance.

本文言語英語
ページ(範囲)472-480
ページ数9
ジャーナルNippon rinsho. Japanese journal of clinical medicine
59
3
出版ステータス出版済み - 1 1 2001
外部発表はい

All Science Journal Classification (ASJC) codes

  • 医学(全般)

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