Pathophysiological roles of NADPH oxidase/Nox family proteins in the vascular system review and perspective

Tetsuro Ago; Junya Kuroda; Masahiro Kamouchi; Junichi Sadoshima; Takanari Kitazono

doi:10.1253/circj.CJ-11-0388

Pathophysiological roles of NADPH oxidase/Nox family proteins in the vascular system review and perspective

Tetsuro Ago, Junya Kuroda, Masahiro Kamouchi, Junichi Sadoshima, Takanari Kitazono

研究成果: Contribution to journal › Review article › 査読

73 被引用数 (Scopus)

抄録

It has been established that oxidative stress plays a crucial role in the development and progression of vascular diseases. Besides the mitochondria, the NADPH oxidase/Nox family proteins are now thought to be important origins of the reactive oxygen species that underlie various vascular disease states, such as hypertension, atherosclerosis, angiogenesis, and ischemia/reperfusion injury. This review summarizes the basis of vascular Nox proteins and discusses their pathophysiological roles in the vascular system.

本文言語	英語
ページ（範囲）	1791-1800
ページ数	10
ジャーナル	Circulation Journal
巻	75
号	8
DOI	https://doi.org/10.1253/circj.CJ-11-0388
出版ステータス	出版済み - 8 2011

All Science Journal Classification (ASJC) codes

循環器および心血管医学

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10.1253/circj.CJ-11-0388

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abstract = "It has been established that oxidative stress plays a crucial role in the development and progression of vascular diseases. Besides the mitochondria, the NADPH oxidase/Nox family proteins are now thought to be important origins of the reactive oxygen species that underlie various vascular disease states, such as hypertension, atherosclerosis, angiogenesis, and ischemia/reperfusion injury. This review summarizes the basis of vascular Nox proteins and discusses their pathophysiological roles in the vascular system.",

author = "Tetsuro Ago and Junya Kuroda and Masahiro Kamouchi and Junichi Sadoshima and Takanari Kitazono",

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AU - Kitazono, Takanari

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N2 - It has been established that oxidative stress plays a crucial role in the development and progression of vascular diseases. Besides the mitochondria, the NADPH oxidase/Nox family proteins are now thought to be important origins of the reactive oxygen species that underlie various vascular disease states, such as hypertension, atherosclerosis, angiogenesis, and ischemia/reperfusion injury. This review summarizes the basis of vascular Nox proteins and discusses their pathophysiological roles in the vascular system.

AB - It has been established that oxidative stress plays a crucial role in the development and progression of vascular diseases. Besides the mitochondria, the NADPH oxidase/Nox family proteins are now thought to be important origins of the reactive oxygen species that underlie various vascular disease states, such as hypertension, atherosclerosis, angiogenesis, and ischemia/reperfusion injury. This review summarizes the basis of vascular Nox proteins and discusses their pathophysiological roles in the vascular system.

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JO - Circulation Journal

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Pathophysiological roles of NADPH oxidase/Nox family proteins in the vascular system review and perspective

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