Pathophysiology of chronic lymphocytic leukemia and human B1 cell development

研究成果: Contribution to journalReview article査読

2 被引用数 (Scopus)

抄録

Chronic lymphocytic leukemia (CLL), the most frequent type of leukemia in adults, is a lymphoproliferative disease characterized by the clonal expansion of mature CD5+ B cells in peripheral blood, bone marrow, and secondary lymphoid tissues. Over the past decade, substantial advances have been made in understanding the pathogenesis of CLL, including the identification of recurrent mutations, and clarification of clonal architectures, transcriptome analyses, and the multistep leukemogenic process. The biology of CLL is now better understood. The present review focuses on recent insights into CLL leukemogenesis, emphasizing the role of genetic lesions, and the multistep process initiating from very immature hematopoietic stem cells. Finally, we also review progress in the study of human B1 B cells, the putative normal counterparts of CLL cells.

本文言語英語
ページ(範囲)634-641
ページ数8
ジャーナルInternational journal of hematology
111
5
DOI
出版ステータス出版済み - 5 1 2020

All Science Journal Classification (ASJC) codes

  • 血液学

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