Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis

Takafumi Toyohara, Filip Roudnicky, Mary H.C. Florido, Toshiaki Nakano, Haojie Yu, Shunsuke Katsuki, Minjin Lee, Torsten Meissner, Max Friesen, Lance S. Davidow, Leon Ptaszek, Takaaki Abe, Lee L. Rubin, Alexandre C. Pereira, Masanori Aikawa, Chad A. Cowan

研究成果: Contribution to journalArticle

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抜粋

Why some patients with type 2 diabetes are protected against cardiovascular disease (CVD) has not been clarified. Toyohara et al. reveal that in patients protected from CVD, arylacetamide deacetylase (AADAC) is elevated in vascular smooth muscle cells (VSMCs). AADAC alters lipid metabolism and cellular processes in VSMCs and ameliorates CVD.

元の言語英語
ページ(範囲)147-157.e7
ジャーナルCell stem cell
27
発行部数1
DOI
出版物ステータス出版済み - 7 2 2020

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Genetics
  • Cell Biology

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    Toyohara, T., Roudnicky, F., Florido, M. H. C., Nakano, T., Yu, H., Katsuki, S., Lee, M., Meissner, T., Friesen, M., Davidow, L. S., Ptaszek, L., Abe, T., Rubin, L. L., Pereira, A. C., Aikawa, M., & Cowan, C. A. (2020). Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis. Cell stem cell, 27(1), 147-157.e7. https://doi.org/10.1016/j.stem.2020.04.018