PEG-modified gold nanorods with a stealth character for in vivo applications

Takuro Niidome, Masato Yamagata, Yuri Okamoto, Yasuyuki Akiyama, Hironobu Takahashi, Takahito Kawano, Yoshiki Katayama, Yasuro Niidome

研究成果: ジャーナルへの寄稿記事

890 引用 (Scopus)

抄録

Gold nanorods prepared in hexadecyltrimethylammonium bromide (CTAB) solution are expected to provide novel materials for photothermal therapy and photo-controlled drug delivery systems. Since gold nanorods stabilized with CTAB show strong cytotoxicity, we developed a technique to modify these with polyethyleneglycol (PEG) for medical applications. PEG-modification was achieved by adding mPEG-SH in the CTAB solution, then, excess CTAB was removed by dialysis. PEG-modified gold nanoparticles showed a nearly neutral surface, and had little cytotoxicity in vitro. Following intravenous injection into mice, 54% of injected PEG-modified gold nanoparticles were found in blood at 0.5 h after intravenous injection, whereas most of gold was detected in the liver in the case of original gold nanorods stabilized with CTAB.

元の言語英語
ページ(範囲)343-347
ページ数5
ジャーナルJournal of Controlled Release
114
発行部数3
DOI
出版物ステータス出版済み - 9 12 2006

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Nanotubes
Gold
Intravenous Injections
Nanoparticles
Drug Delivery Systems
cetrimonium
Dialysis
Liver

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

これを引用

Niidome, T., Yamagata, M., Okamoto, Y., Akiyama, Y., Takahashi, H., Kawano, T., ... Niidome, Y. (2006). PEG-modified gold nanorods with a stealth character for in vivo applications. Journal of Controlled Release, 114(3), 343-347. https://doi.org/10.1016/j.jconrel.2006.06.017

PEG-modified gold nanorods with a stealth character for in vivo applications. / Niidome, Takuro; Yamagata, Masato; Okamoto, Yuri; Akiyama, Yasuyuki; Takahashi, Hironobu; Kawano, Takahito; Katayama, Yoshiki; Niidome, Yasuro.

:: Journal of Controlled Release, 巻 114, 番号 3, 12.09.2006, p. 343-347.

研究成果: ジャーナルへの寄稿記事

Niidome, T, Yamagata, M, Okamoto, Y, Akiyama, Y, Takahashi, H, Kawano, T, Katayama, Y & Niidome, Y 2006, 'PEG-modified gold nanorods with a stealth character for in vivo applications', Journal of Controlled Release, 巻. 114, 番号 3, pp. 343-347. https://doi.org/10.1016/j.jconrel.2006.06.017
Niidome T, Yamagata M, Okamoto Y, Akiyama Y, Takahashi H, Kawano T その他. PEG-modified gold nanorods with a stealth character for in vivo applications. Journal of Controlled Release. 2006 9 12;114(3):343-347. https://doi.org/10.1016/j.jconrel.2006.06.017
Niidome, Takuro ; Yamagata, Masato ; Okamoto, Yuri ; Akiyama, Yasuyuki ; Takahashi, Hironobu ; Kawano, Takahito ; Katayama, Yoshiki ; Niidome, Yasuro. / PEG-modified gold nanorods with a stealth character for in vivo applications. :: Journal of Controlled Release. 2006 ; 巻 114, 番号 3. pp. 343-347.
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AU - Katayama, Yoshiki

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