Peptide-grafted polymers as artificial converter of cellular signals

研究成果: ジャーナルへの寄稿記事

16 引用 (Scopus)

抄録

Intracellular signal transduction systems consisting of sophisticated molecular networks are essential to provide almost all cellular functions. Any abnormal activation of enzymes included in this network can be directly linked to various disease states. Therefore, cellular function can be altered if we can modulate this signal transduction process. In this context, artificial signal converters, which respond to particular abnormal signaling to activate transgene transcription, are introduced. Such molecular systems use polymer materials grafted with cationic peptides, which are a specific substrate of target protein kinase or protease. This concept which is called D-RECS, DDS in response to cellular signals, could have potential for design of disease cell specific therapeutic or diagnostic (imaging) systems using pathological signaling as a target. Molecular design and structural factors affecting signal response in such systems are discussed.

元の言語英語
ページ(範囲)12-21
ページ数10
ジャーナルBulletin of the Chemical Society of Japan
90
発行部数1
DOI
出版物ステータス出版済み - 1 1 2017

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Signal transduction
Polymers
Peptides
Transcription
Imaging systems
Protein Kinases
Peptide Hydrolases
Chemical activation
Substrates
Enzymes

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

これを引用

Peptide-grafted polymers as artificial converter of cellular signals. / Katayama, Yoshiki.

:: Bulletin of the Chemical Society of Japan, 巻 90, 番号 1, 01.01.2017, p. 12-21.

研究成果: ジャーナルへの寄稿記事

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