Peptide vector for gene delivery with high affinity for phosphatidylserine

Shinichi Kuriyama, Yasushi Taguchi, Kanako Nishimura, Kiyoshi Mizuguchi, Kazutoshi Kobayashi, Yoshiki Katayama, Kazutoshi Yanagibashi, Takuro Niidome

研究成果: ジャーナルへの寄稿記事

6 引用 (Scopus)

抄録

Since phosphatidylserine (PS) is known to translocate to the external face of the plasma membrane when the cell membrane becomes disordered, we decided to focus our attention on PS as a target molecule for gene delivery. In this paper, the novel peptide Td3701 was designed, synthesized, and characterized for its physico-chemico-biological properties. Td3701 simultaneously exhibited both characters as a DNA carrier and a sensor probe for active targeting, which seemed to be triggered by structural changes in the presence of PS. This is a very unique character among nonviral vectors, and it is believed that Td3701 could be used for selective gene delivery.

元の言語英語
ページ(範囲)626-632
ページ数7
ジャーナルJournal of Peptide Science
12
発行部数10
DOI
出版物ステータス出版済み - 10 1 2006

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Phosphatidylserines
Genes
Cell membranes
Peptides
Cell Membrane
Molecules
DNA
Sensors

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

これを引用

Kuriyama, S., Taguchi, Y., Nishimura, K., Mizuguchi, K., Kobayashi, K., Katayama, Y., ... Niidome, T. (2006). Peptide vector for gene delivery with high affinity for phosphatidylserine. Journal of Peptide Science, 12(10), 626-632. https://doi.org/10.1002/psc.768

Peptide vector for gene delivery with high affinity for phosphatidylserine. / Kuriyama, Shinichi; Taguchi, Yasushi; Nishimura, Kanako; Mizuguchi, Kiyoshi; Kobayashi, Kazutoshi; Katayama, Yoshiki; Yanagibashi, Kazutoshi; Niidome, Takuro.

:: Journal of Peptide Science, 巻 12, 番号 10, 01.10.2006, p. 626-632.

研究成果: ジャーナルへの寄稿記事

Kuriyama, S, Taguchi, Y, Nishimura, K, Mizuguchi, K, Kobayashi, K, Katayama, Y, Yanagibashi, K & Niidome, T 2006, 'Peptide vector for gene delivery with high affinity for phosphatidylserine', Journal of Peptide Science, 巻. 12, 番号 10, pp. 626-632. https://doi.org/10.1002/psc.768
Kuriyama S, Taguchi Y, Nishimura K, Mizuguchi K, Kobayashi K, Katayama Y その他. Peptide vector for gene delivery with high affinity for phosphatidylserine. Journal of Peptide Science. 2006 10 1;12(10):626-632. https://doi.org/10.1002/psc.768
Kuriyama, Shinichi ; Taguchi, Yasushi ; Nishimura, Kanako ; Mizuguchi, Kiyoshi ; Kobayashi, Kazutoshi ; Katayama, Yoshiki ; Yanagibashi, Kazutoshi ; Niidome, Takuro. / Peptide vector for gene delivery with high affinity for phosphatidylserine. :: Journal of Peptide Science. 2006 ; 巻 12, 番号 10. pp. 626-632.
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