Peptidergic innervation irregularities in Hirschsprung's disease - Immunohistochemistry - Radioimmunoassay

Tomoaki Taguchi, Kenzo Tanaka, Keiichi Ikeda, Sunao Matsubayashi, Noboru Yanaihara

研究成果: Contribution to journalEditorial査読

38 被引用数 (Scopus)

抄録

The distribution of vasoactive intestinal polypeptide (VIP)-containing nerves and the contents of both VIP and substance P (S-P) in the intestines from 12 children with Hirschsprung's disease were examined using immunohistochemical methods and radioimmunoassay. VIP-containing nerve fibers were markedly decreased in number in the true muscle coats of aganglionic segments, while extrinsic hypertrophic nerve bundles in these segments showed positive VIP-immunoreactivities. This finding suggests the existance of extrinsic origins of VIP-containing nerves in the human gut. The contents of VIP were 44.5±8.2 in aganglionic segments and 130 ± 17.1 pg/mg wet tissue weight in normoganglionic segments. The contents of S-P were 0.42 ± 0.18 in aganglionic segments and 6.38 ± 2.3 pg/mg wet tissue weight in normoganglionic segments. Both VIP and S-P contents in aganglionic segments were significantly reduced as assessed by the use of radioimmunoassay (p<0.001 and p<0.05). These abnormal peptidergic patterns of innervation might relate to the non-peristaltic state in Hirschsprung's disease.

本文言語英語
ページ(範囲)223-235
ページ数13
ジャーナルVirchows Archiv A Pathological Anatomy and Histopathology
401
2
DOI
出版ステータス出版済み - 1 1983

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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