Performance of an octacalcium phosphate biomaterial in a long bone defect in ovariectomized rat

Kazuyoshi Baba, Yukari Shiwaku, Takahisa Anada, Yu Mori, Kaori Tsuchiya, Eiji Itoi, Osamu Suzuki

研究成果: 書籍/レポート タイプへの寄稿会議への寄与

抄録

Statement of Purpose: We have reported that octacalcium phosphate (OCP) exhibits direct bone bonding property1 and has in vitro stimulatory capacities on osteoblastic cell differentiation from bone marrow cells not only to osteoblastic cells2,3 but also to late osteocytes4. OCP is also able to enhance formation of osteoclasts from bone marrow cells in the co-presence of osteoblasts5. From these intrinsic mechanisms, OCP is considered to enhance new bone formation coupled with biodegradation6. We hypothesized, therefore, that OCP could be used as a bone substitute material to treat bone defect in pathologic condition such as osteoporotic condition by expressing such cellar stimulatory activities. In the present study, an effect of OCP/gelatin (OCP/Gel) bone substitute material7 on bone formation in a tibial bone defect was investigated using an ovariectomized rat. OCP/Gel has shown to have highly biodegradable characteristics with an immediate bone deposition in a tibial bone defect of a rabbit8. The resorption rate was much higher in OCP/Gel than a high porosity β-tricalcium phosphate (β-TCP).

本文言語英語
ホスト出版物のタイトルSociety for Biomaterials Annual Meeting and Exposition 2019
ホスト出版物のサブタイトルThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
出版社Society for Biomaterials
ページ932
ページ数1
ISBN(電子版)9781510883901
出版ステータス出版済み - 2019
イベント42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, 米国
継続期間: 4月 3 20194月 6 2019

出版物シリーズ

名前Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
40
ISSN(印刷版)1526-7547

会議

会議42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
国/地域米国
CitySeattle
Period4/3/194/6/19

!!!All Science Journal Classification (ASJC) codes

  • 生化学
  • 生物理学
  • バイオテクノロジー
  • 生体材料
  • 材料化学

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