TY - CHAP
T1 - Pericytes in bone marrow
AU - Kunisaki, Yuya
N1 - Publisher Copyright:
© Springer Nature Switzerland AG 2019.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019
Y1 - 2019
N2 - Bone marrow environments are composed of multiple cell types, most of which are thought to be derived from mesenchymal stem cells. In mouse bone marrow, stromal cells with CD45− Tie2− CD90− CD51+ CD105+ phenotype, Nestin-GFP+, CXCL12-abundant reticular (CAR) cells, PDGFRα+ Sca-1+ or CD51+ PDGFRα+, and Prx-1-derived CD45− Ter119− PDGFRα+ Sca-1+ populations select for MSC activity. There is evidence that these stromal cell populations display some significant overlap with each other and comprise important cellular constituents of the hematopoietic stem cell niche. Moreover, these mesenchymal cell populations share characteristics in their location as they all are found around bone marrow vessels (can be called “pericytes”). In this chapter, with reviewing the recent literatures, how the pericytes relate to physiological and pathological hematopoiesis is argued.
AB - Bone marrow environments are composed of multiple cell types, most of which are thought to be derived from mesenchymal stem cells. In mouse bone marrow, stromal cells with CD45− Tie2− CD90− CD51+ CD105+ phenotype, Nestin-GFP+, CXCL12-abundant reticular (CAR) cells, PDGFRα+ Sca-1+ or CD51+ PDGFRα+, and Prx-1-derived CD45− Ter119− PDGFRα+ Sca-1+ populations select for MSC activity. There is evidence that these stromal cell populations display some significant overlap with each other and comprise important cellular constituents of the hematopoietic stem cell niche. Moreover, these mesenchymal cell populations share characteristics in their location as they all are found around bone marrow vessels (can be called “pericytes”). In this chapter, with reviewing the recent literatures, how the pericytes relate to physiological and pathological hematopoiesis is argued.
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U2 - 10.1007/978-3-030-11093-2_6
DO - 10.1007/978-3-030-11093-2_6
M3 - Chapter
C2 - 30937865
AN - SCOPUS:85064222202
T3 - Advances in Experimental Medicine and Biology
SP - 101
EP - 114
BT - Advances in Experimental Medicine and Biology
PB - Springer New York LLC
ER -