抄録
Bone marrow environments are composed of multiple cell types, most of which are thought to be derived from mesenchymal stem cells. In mouse bone marrow, stromal cells with CD45− Tie2− CD90− CD51+ CD105+ phenotype, Nestin-GFP+, CXCL12-abundant reticular (CAR) cells, PDGFRα+ Sca-1+ or CD51+ PDGFRα+, and Prx-1-derived CD45− Ter119− PDGFRα+ Sca-1+ populations select for MSC activity. There is evidence that these stromal cell populations display some significant overlap with each other and comprise important cellular constituents of the hematopoietic stem cell niche. Moreover, these mesenchymal cell populations share characteristics in their location as they all are found around bone marrow vessels (can be called “pericytes”). In this chapter, with reviewing the recent literatures, how the pericytes relate to physiological and pathological hematopoiesis is argued.
| 元の言語 | 英語 |
|---|---|
| ホスト出版物のタイトル | Advances in Experimental Medicine and Biology |
| 出版者 | Springer New York LLC |
| ページ | 101-114 |
| ページ数 | 14 |
| DOI | |
| 出版物ステータス | 出版済み - 1 1 2019 |
出版物シリーズ
| 名前 | Advances in Experimental Medicine and Biology |
|---|---|
| 巻 | 1122 |
| ISSN（印刷物） | 0065-2598 |
| ISSN（電子版） | 2214-8019 |
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All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
これを引用
Pericytes in bone marrow. / Kunisaki, Yuya.
Advances in Experimental Medicine and Biology. Springer New York LLC, 2019. p. 101-114 (Advances in Experimental Medicine and Biology; 巻 1122).研究成果: 著書/レポートタイプへの貢献 › 章
}
TY - CHAP
T1 - Pericytes in bone marrow
AU - Kunisaki, Yuya
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Bone marrow environments are composed of multiple cell types, most of which are thought to be derived from mesenchymal stem cells. In mouse bone marrow, stromal cells with CD45− Tie2− CD90− CD51+ CD105+ phenotype, Nestin-GFP+, CXCL12-abundant reticular (CAR) cells, PDGFRα+ Sca-1+ or CD51+ PDGFRα+, and Prx-1-derived CD45− Ter119− PDGFRα+ Sca-1+ populations select for MSC activity. There is evidence that these stromal cell populations display some significant overlap with each other and comprise important cellular constituents of the hematopoietic stem cell niche. Moreover, these mesenchymal cell populations share characteristics in their location as they all are found around bone marrow vessels (can be called “pericytes”). In this chapter, with reviewing the recent literatures, how the pericytes relate to physiological and pathological hematopoiesis is argued.
AB - Bone marrow environments are composed of multiple cell types, most of which are thought to be derived from mesenchymal stem cells. In mouse bone marrow, stromal cells with CD45− Tie2− CD90− CD51+ CD105+ phenotype, Nestin-GFP+, CXCL12-abundant reticular (CAR) cells, PDGFRα+ Sca-1+ or CD51+ PDGFRα+, and Prx-1-derived CD45− Ter119− PDGFRα+ Sca-1+ populations select for MSC activity. There is evidence that these stromal cell populations display some significant overlap with each other and comprise important cellular constituents of the hematopoietic stem cell niche. Moreover, these mesenchymal cell populations share characteristics in their location as they all are found around bone marrow vessels (can be called “pericytes”). In this chapter, with reviewing the recent literatures, how the pericytes relate to physiological and pathological hematopoiesis is argued.
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UR - http://www.scopus.com/inward/citedby.url?scp=85064222202&partnerID=8YFLogxK
U2 - 10.1007/978-3-030-11093-2_6
DO - 10.1007/978-3-030-11093-2_6
M3 - Chapter
C2 - 30937865
AN - SCOPUS:85064222202
T3 - Advances in Experimental Medicine and Biology
SP - 101
EP - 114
BT - Advances in Experimental Medicine and Biology
PB - Springer New York LLC
ER -