Perillaldehyde inhibits AHR signaling and activates NRF2 antioxidant pathway in human keratinocytes

Yoko Fuyuno, Hiroshi Uchi, Mao Yasumatsu, Saori Morino-Koga, Yuka Tanaka, Chikage Mitoma, Masutaka Furue

研究成果: Contribution to journalArticle査読

8 被引用数 (Scopus)

抄録

The skin covers the outer surface of the body, so the epidermal keratinocytes within it are susceptible to reactive oxygen species (ROS) generated by environmental pollutants such as benzo(a)pyrene (BaP), a potent activator of aryl hydrocarbon receptor (AHR). Antioxidant activity is generally mediated by the nuclear factor-erythroid 2-related factor-2 (NRF2) and heme oxygenase-1 (HO1) axis in human keratinocytes. Perillaldehyde is the main component of Perilla frutescens, which is a medicinal antioxidant herb traditionally consumed in East Asia. However, the effect of perillaldehyde on the AHR/ROS and/or NRF2/HO1 pathways remains unknown. In human keratinocytes, we found that perillaldehyde (1) inhibited BaP-induced AHR activation and ROS production, (2) inhibited BaP/AHR-mediated release of the CCL2 chemokine, and (3) activated the NRF2/HO1 antioxidant pathway. Perillaldehyde is thus potentially useful for managing inflammatory skin diseases or disorders related to oxidative stress.

本文言語英語
論文番号9524657
ジャーナルOxidative medicine and cellular longevity
2018
DOI
出版ステータス出版済み - 2018

All Science Journal Classification (ASJC) codes

  • 生化学
  • 加齢科学
  • 細胞生物学

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