Periodontal disease and diabetes mellitus: The role of tumor necrosis factor-α in a 2-way relationship

Fusanori Nishimura, Yoshihiro Iwamoto, Junji Mineshiba, Akemi Shimizu, Yoshihiko Soga, Yoji Murayama

研究成果: ジャーナルへの寄稿総説査読

175 被引用数 (Scopus)


It is generally accepted that obesity is associated with many other multiple-risk factor syndromes such as hypertension, hyperlipidemia, type 2 diabetes mellitus, and periodontal disease. The number of obese people is increasing rapidly in both western and eastern countries. Adipocytes in the adipose tissues of obese people produce large quantities of biologically active molecules such as leptin, an important molecule regulating energy expenditure and body weight. Therefore, adipocyte-derived active molecules, named adipocytokines, are candidate molecules accounting for the close association between obesity and other multiple-risk factor syndromes. The proinflammatory cytokine tumor necrosis factor-α (TNF-α) is produced by adipocytes, and its blood concentration is elevated in obese patients and declines with weight loss. Studies have demonstrated that TNF-α suppresses insulin action via its specific receptor; hence, it exacerbates insulin resistance. In addition to adipocytes, monocytes/macrophages produce large quantities of TNF-α. Thus, TNF-α, produced from monocytic cells due to inflammatory diseases, may have an additive influence on insulin sensitivity to adipocyte-derived TNF-α. Here, we hypothesized that 1) TNF-α produced by the adipose tissues of obese patients acts as a risk factor for periodontal inflammation, and 2) TNF-α produced due to periodontal inflammation may be an additional important factor influencing insulin sensitivity in both obese and type 2 diabetic patients. We believe that this interaction is a possible mechanism accounting for a 2-way relationship between type 2 diabetes and periodontal disease.

ジャーナルJournal of periodontology
出版ステータス出版済み - 1月 1 2003

!!!All Science Journal Classification (ASJC) codes

  • 歯周病学


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