Periostin promotes chronic allergic inflammation in response to Th2 cytokines

Miho Masuoka, Hiroshi Shiraishi, Shoichiro Ohta, Shoichi Suzuki, Kazuhiko Arima, Shigehisa Aoki, Shuji Toda, Naoki Inagaki, Yuichi Kurihara, Sayaka Hayashida, Satoshi Takeuchi, Kenta Koike, Junya Ono, Hirokazu Noshiro, Masutaka Furue, Simon J. Conway, Yutaka Narisawa, Kenji Izuhara

研究成果: ジャーナルへの寄稿学術誌査読

293 被引用数 (Scopus)

抄録

Allergic inflammation triggered by exposure of an allergen frequently leads to the onset of chronic inflammatory diseases such as atopic dermatitis (AD) and bronchial asthma. The mechanisms underlying chronicity in allergic inflammation remain unresolved. Periostin, a recently characterized matricellular protein, interacts with several cell surface integrin molecules, providing signals for tissue development and remodeling. Here we show that periostin is a critical mediator for the amplification and persistence of allergic inflammation using a mouse model of skin inflammation. Th2 cytokines IL-4 and IL-13 stimulated fibroblasts to produce periostin, which interacted with α v integrin, a functional periostin receptor on keratinocytes, inducing production of proinflammatory cytokines, which consequently accelerated Th2-type immune responses. Accordingly, inhibition of periostin or α v integrin prevented the development or progression of allergen-induced skin inflammation. Thus, periostin sets up a vicious circle that links Th2-type immune responses to keratinocyte activation and plays a critical role in the amplification and chronicity of allergic skin inflammation.

本文言語英語
ページ(範囲)2590-2600
ページ数11
ジャーナルJournal of Clinical Investigation
122
7
DOI
出版ステータス出版済み - 7月 2 2012

!!!All Science Journal Classification (ASJC) codes

  • 医学(全般)

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