Peritoneal exudation of macrophages by irritants and its effect on immune responses against sheep erythrocytes and Listeria monocytogenes

S. Miake, K. Nomoto, T. Matsumoto, Yasunobu Yoshikai, K. Takeya

    研究成果: ジャーナルへの寄稿記事

    抄録

    Relation between the degradation of antigenic substances by peritoneal exudate macrophages induced by different irritants and subsequent induction of immune response against SRBC or Listeria monocytogenes were studied. Delayed footpad reaction and antibody production to SRBC were both suppressed by pretreatment with thioglycollate or with killed Corynebacterium parvum. In contrast, delayed footpad reaction and acquired cellular resistance to Listeria were augmented by pretreatment with thioglycollate. When pretreated with C. parvum however, such augmentations in immune responses to Listeria were not observed but these responses were suppressed. It was suggested that the amount of antigenic stimuli was determined by the mutual relationship between the level of macrophage activity as scavenger cells and the suceptibilities of the antigenic substances to degradation by macrophages, and that induction of immune responses were affected by this mutual relationship.

    元の言語英語
    ページ(範囲)95-102
    ページ数8
    ジャーナルJapanese Journal of Experimental Medicine
    53
    発行部数2
    出版物ステータス出版済み - 12 1 1983

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    Thioglycolates
    Propionibacterium acnes
    Listeria
    Irritants
    Listeria monocytogenes
    Peritoneal Macrophages
    Sheep
    Erythrocytes
    Macrophages
    Exudates and Transudates
    Antibody Formation

    All Science Journal Classification (ASJC) codes

    • Medicine(all)

    これを引用

    Peritoneal exudation of macrophages by irritants and its effect on immune responses against sheep erythrocytes and Listeria monocytogenes. / Miake, S.; Nomoto, K.; Matsumoto, T.; Yoshikai, Yasunobu; Takeya, K.

    :: Japanese Journal of Experimental Medicine, 巻 53, 番号 2, 01.12.1983, p. 95-102.

    研究成果: ジャーナルへの寄稿記事

    Miake, S. ; Nomoto, K. ; Matsumoto, T. ; Yoshikai, Yasunobu ; Takeya, K. / Peritoneal exudation of macrophages by irritants and its effect on immune responses against sheep erythrocytes and Listeria monocytogenes. :: Japanese Journal of Experimental Medicine. 1983 ; 巻 53, 番号 2. pp. 95-102.
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    abstract = "Relation between the degradation of antigenic substances by peritoneal exudate macrophages induced by different irritants and subsequent induction of immune response against SRBC or Listeria monocytogenes were studied. Delayed footpad reaction and antibody production to SRBC were both suppressed by pretreatment with thioglycollate or with killed Corynebacterium parvum. In contrast, delayed footpad reaction and acquired cellular resistance to Listeria were augmented by pretreatment with thioglycollate. When pretreated with C. parvum however, such augmentations in immune responses to Listeria were not observed but these responses were suppressed. It was suggested that the amount of antigenic stimuli was determined by the mutual relationship between the level of macrophage activity as scavenger cells and the suceptibilities of the antigenic substances to degradation by macrophages, and that induction of immune responses were affected by this mutual relationship.",
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    AU - Yoshikai, Yasunobu

    AU - Takeya, K.

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