Permeability of a sol-gel synthesized aminopropyl-silicate-titanate hybrid membrane for the microcapsule-shaped bioartificial pancreas

S. Sakai, T. Ono, H. Ijima, K. Kawakami

研究成果: ジャーナルへの寄稿学術誌査読

1 被引用数 (Scopus)

抄録

The aminopropyl-silicate-titanate hybrid membrane was successfully synthesized onto a Ca-alginate gel bead by the sol-gel method, from two kinds of organometallic compound precursors, tetraethyl orthotitanate (TEOTi) [Ti(OC2H5)4] and 3-aminopropyltrimethyl orthosilicate (APTrMOS) [(CH3O)3Si(CH2)3NH2]. APTrMOS acted as a binding agent between inorganic titanate and alginate polymer via electrostatic interaction between amino groups of APTrMOS and carboxyl groups of alginate. From the measurements of the diffusion of ovalbumin and γ-globulin through the aminopropyl-silicate-titanate hybrid membrane, it was found that the molecular permeability of the membrane could be controlled by changing the amount of each precursor. The molecular weight cutoff point required for immunoisolation, less than 150kDa, was achieved under the condition that the amount of APTrMOS was 3.40 mmol/ (10 ml of Ca-alginate) and TEOTi was more than 1.42 mmol. The islets encapsulated in the membrane showed almost the same insulin secretion viability as the free islets.

本文言語英語
ページ(範囲)54-59
ページ数6
ジャーナルJournal of Artificial Organs
5
1
DOI
出版ステータス出版済み - 1月 1 2002

!!!All Science Journal Classification (ASJC) codes

  • 医学(その他)
  • 生体材料
  • 生体医工学
  • 循環器および心血管医学

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