Permeability studies of nitroxyl spin probes through lipid membranes using L-band ESR spectrometer

A. Milton Franklin Benial, M. Kumara Dhas, Kazuhiro Ichikawa, Ken-Ichi Yamada, Fuminori Hyodo, A. Jawahar, Hideo Utsumi

研究成果: Chapter in Book/Report/Conference proceedingConference contribution

抄録

Electron spin resonance studies were carried out for 2mM 14N labeled 2H enriched 3-methoxycarbonyl-2,2,5,5-tetramethyl- pyrrolidine-1-oxyl (MC-PROXYL) in pure water and 100, 200, 300, 400 mM concentrations of liposomal solution and 3-carboxy-2,2,5,5,-tetramethyl-1- pyrrolidinyloxy (carboxy-PROXYL) in pure water and 400 mM concentration of liposomal solution by using L-band ESR spectrometer. This study reveals that the permeability of MC-PROXYL in liposomal solution and impermeability of carboxy-PROXYL in 400 mM concentration of liposomal solution. This study illustrates that the ESR can be used to differentiate between the intra-and extra-membrane water by loading the liposome vesicles with a lipid permeable nitroxyl spin probe. The lipid membrane permeability of two different nitroxyl spin probes was demonstrated.

本文言語英語
ホスト出版物のタイトルSolid State Physics - Proceedings of the 56th DAE Solid State Physics Symposium 2011
ページ185-186
ページ数2
1
DOI
出版ステータス出版済み - 12 1 2012
イベント56th DAE Solid State Physics Symposium 2011 - Kattankulathur, Tamilnadu, インド
継続期間: 12 19 201112 23 2011

出版物シリーズ

名前AIP Conference Proceedings
番号1
1447
ISSN(印刷版)0094-243X
ISSN(電子版)1551-7616

その他

その他56th DAE Solid State Physics Symposium 2011
国/地域インド
CityKattankulathur, Tamilnadu
Period12/19/1112/23/11

All Science Journal Classification (ASJC) codes

  • 物理学および天文学(全般)

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