抄録
Electron spin resonance (ESR) studies were carried out for 2mM 14N-labeled deutrated 3-methoxycarbonyl-2,2,5,5-tetramethyl- pyrrolidine-1-oxyl (MC-PROXYL) and 3-carboxy-2,2,5,5,-tetramethyl-1- pyrrolidinyloxy (carboxy-PROXYL) in pure water and various concentrations of liposomal solutions by using 300 MHz ESR spectrometer. The ESR parameters such as the line width, hyperfine coupling constant, g-factor, rotational correlation time, partition parameter and permeability were reported for the samples. The permeable and impermeable nature of nitroxyl spin probes was demonstrated. The increased rotational correlation time was observed for MC-PROXYL, which indicates the permeable and less mobile nature of the nitroxyl spin probe. The obtained partition parameter and permeability values are used to quantify the permeable nature of the nitroxyl spin probe. The peaks correspond to lipid phase were observed for MC-PROXYL in liposomal solution, but that peak was not observed for carboxy-PROXYL. These results indicate the permeable and the impermeable nature of nitroxyl spin probes.
| 元の言語 | 英語 |
|---|---|
| ホスト出版物のタイトル | Solid State Physics - Proceedings of the 57th DAE Solid State Physics Symposium 2012 |
| ページ | 132-133 |
| ページ数 | 2 |
| DOI | |
| 出版物ステータス | 出版済み - 3 15 2013 |
| イベント | 57th DAE Solid State Physics Symposium 2012 - Bombay, Mumbai, インド 継続期間: 12 3 2012 → 12 7 2012 |
出版物シリーズ
| 名前 | AIP Conference Proceedings |
|---|---|
| 巻 | 1512 |
| ISSN（印刷物） | 0094-243X |
| ISSN（電子版） | 1551-7616 |
その他
| その他 | 57th DAE Solid State Physics Symposium 2012 |
|---|---|
| 国 | インド |
| 市 | Bombay, Mumbai |
| 期間 | 12/3/12 → 12/7/12 |
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All Science Journal Classification (ASJC) codes
- Ecology, Evolution, Behavior and Systematics
- Ecology
- Plant Science
- Physics and Astronomy(all)
- Nature and Landscape Conservation
これを引用
Permeability studies of redox-sensitive nitroxyl radicals through bilayer lipid membranes. / Dhas, M. Kumara; Benial, A. Milton Franklin; Ichikawa, Kazuhiro; Yamada, Ken-Ichi; Hyodo, Fuminori; Jawahar, A.; Utsumi, Hideo.
Solid State Physics - Proceedings of the 57th DAE Solid State Physics Symposium 2012. 2013. p. 132-133 (AIP Conference Proceedings; 巻 1512).研究成果: 著書/レポートタイプへの貢献 › 会議での発言
}
TY - GEN
T1 - Permeability studies of redox-sensitive nitroxyl radicals through bilayer lipid membranes
AU - Dhas, M. Kumara
AU - Benial, A. Milton Franklin
AU - Ichikawa, Kazuhiro
AU - Yamada, Ken-Ichi
AU - Hyodo, Fuminori
AU - Jawahar, A.
AU - Utsumi, Hideo
PY - 2013/3/15
Y1 - 2013/3/15
N2 - Electron spin resonance (ESR) studies were carried out for 2mM 14N-labeled deutrated 3-methoxycarbonyl-2,2,5,5-tetramethyl- pyrrolidine-1-oxyl (MC-PROXYL) and 3-carboxy-2,2,5,5,-tetramethyl-1- pyrrolidinyloxy (carboxy-PROXYL) in pure water and various concentrations of liposomal solutions by using 300 MHz ESR spectrometer. The ESR parameters such as the line width, hyperfine coupling constant, g-factor, rotational correlation time, partition parameter and permeability were reported for the samples. The permeable and impermeable nature of nitroxyl spin probes was demonstrated. The increased rotational correlation time was observed for MC-PROXYL, which indicates the permeable and less mobile nature of the nitroxyl spin probe. The obtained partition parameter and permeability values are used to quantify the permeable nature of the nitroxyl spin probe. The peaks correspond to lipid phase were observed for MC-PROXYL in liposomal solution, but that peak was not observed for carboxy-PROXYL. These results indicate the permeable and the impermeable nature of nitroxyl spin probes.
AB - Electron spin resonance (ESR) studies were carried out for 2mM 14N-labeled deutrated 3-methoxycarbonyl-2,2,5,5-tetramethyl- pyrrolidine-1-oxyl (MC-PROXYL) and 3-carboxy-2,2,5,5,-tetramethyl-1- pyrrolidinyloxy (carboxy-PROXYL) in pure water and various concentrations of liposomal solutions by using 300 MHz ESR spectrometer. The ESR parameters such as the line width, hyperfine coupling constant, g-factor, rotational correlation time, partition parameter and permeability were reported for the samples. The permeable and impermeable nature of nitroxyl spin probes was demonstrated. The increased rotational correlation time was observed for MC-PROXYL, which indicates the permeable and less mobile nature of the nitroxyl spin probe. The obtained partition parameter and permeability values are used to quantify the permeable nature of the nitroxyl spin probe. The peaks correspond to lipid phase were observed for MC-PROXYL in liposomal solution, but that peak was not observed for carboxy-PROXYL. These results indicate the permeable and the impermeable nature of nitroxyl spin probes.
UR - http://www.scopus.com/inward/record.url?scp=84874838472&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84874838472&partnerID=8YFLogxK
U2 - 10.1063/1.4790946
DO - 10.1063/1.4790946
M3 - Conference contribution
SN - 9780735411333
T3 - AIP Conference Proceedings
SP - 132
EP - 133
BT - Solid State Physics - Proceedings of the 57th DAE Solid State Physics Symposium 2012
ER -