Permeability studies of redox-sensitive nitroxyl radicals through bilayer lipid membranes

M. Kumara Dhas, A. Milton Franklin Benial, Kazuhiro Ichikawa, Ken-Ichi Yamada, Fuminori Hyodo, A. Jawahar, Hideo Utsumi

研究成果: 著書/レポートタイプへの貢献会議での発言

抄録

Electron spin resonance (ESR) studies were carried out for 2mM 14N-labeled deutrated 3-methoxycarbonyl-2,2,5,5-tetramethyl- pyrrolidine-1-oxyl (MC-PROXYL) and 3-carboxy-2,2,5,5,-tetramethyl-1- pyrrolidinyloxy (carboxy-PROXYL) in pure water and various concentrations of liposomal solutions by using 300 MHz ESR spectrometer. The ESR parameters such as the line width, hyperfine coupling constant, g-factor, rotational correlation time, partition parameter and permeability were reported for the samples. The permeable and impermeable nature of nitroxyl spin probes was demonstrated. The increased rotational correlation time was observed for MC-PROXYL, which indicates the permeable and less mobile nature of the nitroxyl spin probe. The obtained partition parameter and permeability values are used to quantify the permeable nature of the nitroxyl spin probe. The peaks correspond to lipid phase were observed for MC-PROXYL in liposomal solution, but that peak was not observed for carboxy-PROXYL. These results indicate the permeable and the impermeable nature of nitroxyl spin probes.

元の言語英語
ホスト出版物のタイトルSolid State Physics - Proceedings of the 57th DAE Solid State Physics Symposium 2012
ページ132-133
ページ数2
DOI
出版物ステータス出版済み - 3 15 2013
イベント57th DAE Solid State Physics Symposium 2012 - Bombay, Mumbai, インド
継続期間: 12 3 201212 7 2012

出版物シリーズ

名前AIP Conference Proceedings
1512
ISSN(印刷物)0094-243X
ISSN(電子版)1551-7616

その他

その他57th DAE Solid State Physics Symposium 2012
インド
Bombay, Mumbai
期間12/3/1212/7/12

Fingerprint

lipids
permeability
membranes
electron paramagnetic resonance
probes
partitions
spectrometers
water

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Ecology
  • Plant Science
  • Physics and Astronomy(all)
  • Nature and Landscape Conservation

これを引用

Dhas, M. K., Benial, A. M. F., Ichikawa, K., Yamada, K-I., Hyodo, F., Jawahar, A., & Utsumi, H. (2013). Permeability studies of redox-sensitive nitroxyl radicals through bilayer lipid membranes. : Solid State Physics - Proceedings of the 57th DAE Solid State Physics Symposium 2012 (pp. 132-133). (AIP Conference Proceedings; 巻数 1512). https://doi.org/10.1063/1.4790946

Permeability studies of redox-sensitive nitroxyl radicals through bilayer lipid membranes. / Dhas, M. Kumara; Benial, A. Milton Franklin; Ichikawa, Kazuhiro; Yamada, Ken-Ichi; Hyodo, Fuminori; Jawahar, A.; Utsumi, Hideo.

Solid State Physics - Proceedings of the 57th DAE Solid State Physics Symposium 2012. 2013. p. 132-133 (AIP Conference Proceedings; 巻 1512).

研究成果: 著書/レポートタイプへの貢献会議での発言

Dhas, MK, Benial, AMF, Ichikawa, K, Yamada, K-I, Hyodo, F, Jawahar, A & Utsumi, H 2013, Permeability studies of redox-sensitive nitroxyl radicals through bilayer lipid membranes. : Solid State Physics - Proceedings of the 57th DAE Solid State Physics Symposium 2012. AIP Conference Proceedings, 巻. 1512, pp. 132-133, 57th DAE Solid State Physics Symposium 2012, Bombay, Mumbai, インド, 12/3/12. https://doi.org/10.1063/1.4790946
Dhas MK, Benial AMF, Ichikawa K, Yamada K-I, Hyodo F, Jawahar A その他. Permeability studies of redox-sensitive nitroxyl radicals through bilayer lipid membranes. : Solid State Physics - Proceedings of the 57th DAE Solid State Physics Symposium 2012. 2013. p. 132-133. (AIP Conference Proceedings). https://doi.org/10.1063/1.4790946
Dhas, M. Kumara ; Benial, A. Milton Franklin ; Ichikawa, Kazuhiro ; Yamada, Ken-Ichi ; Hyodo, Fuminori ; Jawahar, A. ; Utsumi, Hideo. / Permeability studies of redox-sensitive nitroxyl radicals through bilayer lipid membranes. Solid State Physics - Proceedings of the 57th DAE Solid State Physics Symposium 2012. 2013. pp. 132-133 (AIP Conference Proceedings).
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