Persistent elevation of immunoglobulin G titer against the C region of recombinant group A streptococcal M protein in patients with rheumatic fever

Kazuhiro Mori, Nobuhiro Kamikawaji, Takehiko Sasazuki

研究成果: Contribution to journalArticle査読

7 被引用数 (Scopus)

抄録

To analyze the immune response to the C region of group A streptococcal M protein in patients with rheumatic fever (RF), we cloned the structural gene for the C region of type 12 M protein and produced recombinant C region of M protein. IgG titers against the C region of M protein were measured by ELISA from sera of patients with RF (n = 10), uncomplicated streptococcal pharyngitis (n = 26), and age-matched controls (n = 49). IgG titers against the C-region were significantly higher in patients with RF than in controls or patients with uncomplicated streptococcal pharyngitis (43 versus 1.5 or 1.8 μg/mL, p < 0.01). Studies using overlapping synthetic peptides of the C region demonstrated that increased IgG reactivity was observed against the amino-terminal halves of the C repeat blocks (C1, C2) in RF, indicating that these domains are the main immunodominant epitopes in the C region.

本文言語英語
ページ(範囲)336-342
ページ数7
ジャーナルPediatric Research
39
2
DOI
出版ステータス出版済み - 2 1996

All Science Journal Classification (ASJC) codes

  • 小児科学、周産期医学および子どもの健康

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