Pertussis toxin suppresses long-term potentiation of hippocampal mossy fiber synapses

Isao Ito, Daisuke Okada, Hiroyuki Sugiyama

研究成果: ジャーナルへの寄稿記事

42 引用 (Scopus)

抜粋

The long-term potentiation (LTP) was studied using rat hippocampal slices in vitro. LTP in mossy fiber-CA3 pyramidal cell synapses was markedly suppressed in slices prepared from rats which had previously received intraventricular injection of pertussis toxin (PTX), compared with the bovine serum albumin-injected controls, suggesting the involvement of G-proteins in the mechanism of LTP in mossy fiber synapses. In contrast, LTP in Schaffer/commissural-CA1 pyramidal synapses was not affected by PTX pretreatment.

元の言語英語
ページ(範囲)181-185
ページ数5
ジャーナルNeuroscience Letters
90
発行部数1-2
DOI
出版物ステータス出版済み - 7 19 1988
外部発表Yes

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All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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