Pharmacokinetic study of valproic acid sustained-release preparation in patients undergoing brain surgery

I. Ieiri, T. Morioka, T. Ichimiya, S. Nishio, M. Fukui, K. Ohtsubo, S. Higuchi

研究成果: Contribution to journalArticle査読

4 被引用数 (Scopus)

抄録

Pharmacokinetics of valproic acid sustained-release preparation (VPA-SR) were studied in nine patients undergoing surgery for brain tumor. Total (t) and free (f) serum concentrations were analyzed in samples drawn during the day of brain surgery and compared with levels from a postoperative day. The area under the curve (AUCt) and clearance (CLt) of the total concentration did not differ on these occasions. In contrast, statistically significant differences were observed in AUCf and CLf between the two occasions; increased AUCf and decreased CLf were observed on the day of surgery. A significant relation was found between the average free fraction (AUCf/AUCt on operation day per AUCf/AUCt on postoperative day) and estimated blood loss during operation (r = 0.82; p < 0.001). In addition, a significant relation was found between simple free fraction and the intraoperative albumin level in serum (r = −0.68; p < 0.001). These findings indicate that the increased VPA free concentration is due to low serum albumin level secondary to blood loss and that there has been a decrease in intrinsic clearance during operation.

本文言語英語
ページ(範囲)6-11
ページ数6
ジャーナルTherapeutic drug monitoring
17
1
DOI
出版ステータス出版済み - 2 1995

All Science Journal Classification (ASJC) codes

  • 薬理学
  • 薬理学(医学)

フィンガープリント

「Pharmacokinetic study of valproic acid sustained-release preparation in patients undergoing brain surgery」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル