Pharmacotherapy for pediatric chronic intestinal pseudo-obstruction: Nationwide survey in Japan

Naoki Hashizume, Minoru Yagi, Kosuke Ushijima, Yoshitaka Seki, Suguru Fukahori, Mitsuru Muto, Hiroshi Matsufuji, Tomoaki Taguchi

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)


Background: Chronic intestinal pseudo-obstruction (CIPO) is a rare disabling and life-threatening disorder characterized by severe impairment of gastrointestinal peristalsis. While a number of pharmacotherapeutics have been developed, only a few trials have been carried out for improvement of the pathological condition of CIPO patients. This report describes the results of a nationwide survey on the pharmacotherapy used in pediatric CIPO in Japan. Methods: In 2012, a nationwide survey was conducted to identify the clinical presentation of CIPO in Japan. Information was gathered on pharmacotherapy. Four categories were created for medicines used in pharmacotherapy: “probiotics”, “Japanese herbal medicines (Kampo medicines)”, “laxatives”, and “prokinetics”. Results: Ninety-two responses were collected from 47 facilities. Of the 62 patients who met the diagnostic criteria, 52 were treated with medications, while the remaining 10 were not. Thirty-four patients were given a total of 49 probiotics; 39 were treated with a total of 50 Kampo medicines; 20 were treated with a total of 28 laxatives; and 26 were given a total of 30 prokinetics, 70% of whom were treated specifically with mosapride. Conclusion: Traditional Japanese medicines such as Kampo medicines and mosapride are often used to treat CIPO in Japan. Two combinations, that is, probiotics and Kampo medicines; and Kampo medicines and prokinetics, were often used for pediatric CIPO in Japan.

ジャーナルPediatrics International
出版物ステータス出版済み - 4 1 2017


All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health


Hashizume, N., Yagi, M., Ushijima, K., Seki, Y., Fukahori, S., Muto, M., ... Taguchi, T. (2017). Pharmacotherapy for pediatric chronic intestinal pseudo-obstruction: Nationwide survey in Japan. Pediatrics International, 59(4), 467-472.