Phosphate anion chelation and base-pairing. Design of receptors and carriers for nucleotides and nucleotide analogues

Jonathan L. Sessler, Hiroyuki Furuta, Vladimir Kral

研究成果: Contribution to journalArticle査読

68 被引用数 (Scopus)

抄録

A rational approach to the development of effective carriers for the through-membrane transport of GMP (guanosine 5 -monophosphate) at neutral pH is described. The approach detailed is a ditopic one predicated on the use of nucleic acid-base ‘nucleobase’ subunits to provide stabilizing hydrogen bonding interactions and the use of expanded porphyrin anion binding subunits to provide phosphate chelation. Appropriate background studies along with the synthesis of a functioning state-of-the-art system are reported. In addition, the reasons for preparing such GMP transport systems are presented in full.

本文言語英語
ページ(範囲)209-220
ページ数12
ジャーナルSupramolecular Chemistry
1
3-4
DOI
出版ステータス出版済み - 1 1 1993
外部発表はい

All Science Journal Classification (ASJC) codes

  • 化学 (全般)

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